ID   R5UJU2_9FIRM            Unreviewed;       381 AA.
AC   R5UJU2;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein {ECO:0000259|Pfam:PF00465};
GN   ORFNames=BN518_02069 {ECO:0000313|EMBL:CCZ78528.1};
OS   Roseburia sp. CAG:18.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=1262941 {ECO:0000313|EMBL:CCZ78528.1, ECO:0000313|Proteomes:UP000018230};
RN   [1] {ECO:0000313|EMBL:CCZ78528.1, ECO:0000313|Proteomes:UP000018230}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:18 {ECO:0000313|Proteomes:UP000018230};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00007358}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCZ78528.1}.
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DR   EMBL; CBAP010000102; CCZ78528.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5UJU2; -.
DR   Proteomes; UP000018230; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd08176; LPO; 1.
DR   Gene3D; 3.40.50.1970; -; 1.
DR   Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR   InterPro; IPR013460; Lactal_redase.
DR   NCBIfam; TIGR02638; lactal_redase; 1.
DR   PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR11496:SF102; ALCOHOL DEHYDROGENASE 4; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR   PROSITE; PS00913; ADH_IRON_1; 1.
DR   PROSITE; PS00060; ADH_IRON_2; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018230}.
FT   DOMAIN          11..373
FT                   /note="Alcohol dehydrogenase iron-type/glycerol
FT                   dehydrogenase GldA"
FT                   /evidence="ECO:0000259|Pfam:PF00465"
SQ   SEQUENCE   381 AA;  40892 MW;  4145E71C70FD1B68 CRC64;
     MANRIMLNET SYHGAGAIQE IATEAKAHGF QKAFVCSDPD LIKFGVTKKV TDVLDKNGLV
     YEIYSDIKPN PTIQNVQHGV QAFKDSGADY LIAIGGGSSM DTSKAIGIII ANPEFEDVRS
     LEGVAPTKKP CVPIIAVPTT AGTAAEVTIN YVITDVEKKR KFVCVDPHDM PIIAIVDPEM
     MSSMPKGLTA STGMDALTHA IEGYTTKAAW EMTDMFHLKA IELISKSLRS AVANEKEGRE
     GMALGEYIAG MGFSNVGLGI AHSMAHTLGA VYDTPHGVAC AMMLPIVMEY NADCTGEKYR
     EIARAMGVKG VDEMSVDEYR KAAIDAVQQL SVDVGIPTKL EALKEEDLQF LAESAHADAC
     APGNPKDASV EDLKALFRKL M
//