ID R5VPY4_9FIRM Unreviewed; 585 AA.
AC R5VPY4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=BN751_01998 {ECO:0000313|EMBL:CCZ92873.1};
OS Coprococcus eutactus CAG:665.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Coprococcus.
OX NCBI_TaxID=1263071 {ECO:0000313|EMBL:CCZ92873.1, ECO:0000313|Proteomes:UP000017949};
RN [1] {ECO:0000313|EMBL:CCZ92873.1, ECO:0000313|Proteomes:UP000017949}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:665 {ECO:0000313|Proteomes:UP000017949};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ92873.1}.
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DR EMBL; CBAW010000073; CCZ92873.1; -; Genomic_DNA.
DR AlphaFoldDB; R5VPY4; -.
DR Proteomes; UP000017949; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.8.50; -; 1.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR010979; Ribosomal_uS13-like_H2TH.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
DR SUPFAM; SSF46946; S13-like H2TH domain; 1.
PE 3: Inferred from homology;
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 464..558
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
SQ SEQUENCE 585 AA; 66711 MW; E478F82979021427 CRC64;
MAFDGIVISN VVRDMKEKLV DGRIYKIYQP EKDELNIVIK NNRENYRLLI SADASLPLIY
FQQSAKENPM TAPNFCMLLR KHINNGRIVD IYQPGFERIV VIVIEHLDEM GDLKRKKLIT
EIMGKHSNII FATDDDIIID SIKHISHMIS SVREVLPGRT YEYPPAGGKV SPLEITEENF
RERVKESPVN IIKAIYQNIT GFSPVAAAEI CYRAGLDGNA STASLSEGDM DSLYSSFAGV
VSDIKSENYV PQIVIDRYTP VEFSSIEMTM YVDKMIEYRE NISQVLDEYF YRKSAVTRIR
QKSADLRKIV SNAIERTSKK YDLQLKQLKD TESREKYRIY GELINTYGYG IEPGTESFEA
LNYYTDEMVK IPLDKTISVM DNSKRYFAKY NKLKRTYEAL AALTVETKEE LDHLISVQTF
LDMAIDENSL TQVKEELVAC GYIKGHYGRN GDRKGDRKAV KAKPLHYISR DGFHMYVGKN
NIQNDELTFK LANGGDMWFH AKKMPGSHVV VRLEGAGELP DSTYEEAARL AAYYSSGRTA
PKVEIDYTER RNIKKPTGAK PGFVIYHTNY SMIAEPQIAG IKELV
//
