ID   R5WWK3_9FIRM            Unreviewed;       596 AA.
AC   R5WWK3;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Xaa-Pro aminopeptidase {ECO:0000313|EMBL:CDA06935.1};
GN   ORFNames=BN568_01043 {ECO:0000313|EMBL:CDA06935.1};
OS   Blautia sp. CAG:257.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=1262756 {ECO:0000313|EMBL:CDA06935.1, ECO:0000313|Proteomes:UP000018056};
RN   [1] {ECO:0000313|EMBL:CDA06935.1, ECO:0000313|Proteomes:UP000018056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:257 {ECO:0000313|Proteomes:UP000018056};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA06935.1}.
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DR   EMBL; CBBB010000313; CDA06935.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5WWK3; -.
DR   STRING; 1262756.BN568_01043; -.
DR   Proteomes; UP000018056; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 2.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000313|EMBL:CDA06935.1};
KW   Hydrolase {ECO:0000313|EMBL:CDA06935.1};
KW   Protease {ECO:0000313|EMBL:CDA06935.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018056}.
FT   DOMAIN          6..133
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          312..527
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          536..596
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   596 AA;  67055 MW;  C1E78A3B9DBB6763 CRC64;
     MTVQERLAAL RSLMKEKHVD AYLVPTDDFH GSEYVGDYFK CRKYITGFTG SAGTAVITSD
     MAGLWTDGRY FIQAAQQLEG TTVTLFKMGE PKVPTVHEFL KDKLTEGMCL GFDGRCVSAA
     EAEELKSLLA DKNISFSVED DLIGEIWNDR PELSCQPVME LEEKWTGKSR AEKCAQIRDK
     MAEKGADAFI LTSLDDIAWL LNIRGNDIHC CPVVLSYLVM TQDEILLFAN EKAFDAAVRT
     SLEKDGVVLK PYNDIYQYVK TVPENRTVLL SRKSANSRLV SSLPESVKIL DEENLTLLPK
     AIKNPVEVEN ERIAHIKDGV AVTKFIYWLK KNVGKTTITE LSAADHLFSL RKEQENFLDN
     SFDPIVSYAG HAAICHYSPS PETDIPLEPH GLALCDTGGH YLEGSTDITR TVVLGPVTEK
     EKKYFTLVLK GHLNLAAAKF RYGCTDLNLD YIAREPLWQL GEDYNHGTGH GVGYLLNVHE
     GPNRFRWKTA PGQSACVLEE GMITSNEPGY YVENEFGIRH ENLIVCKKAE KTAYGQFMCF
     ENLTMVPFDL DGIAPELLSA HEKELLNQYH AEVYKKISPY LDEEEKQWLK EATREI
//