ID R5XWC3_9FIRM Unreviewed; 849 AA.
AC R5XWC3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Putative translation elongation factor G {ECO:0000313|EMBL:CDA19413.1};
GN ORFNames=BN680_00466 {ECO:0000313|EMBL:CDA19413.1};
OS Ruminococcus sp. CAG:488.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1262959 {ECO:0000313|EMBL:CDA19413.1, ECO:0000313|Proteomes:UP000018248};
RN [1] {ECO:0000313|EMBL:CDA19413.1, ECO:0000313|Proteomes:UP000018248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:488 {ECO:0000313|Proteomes:UP000018248};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA19413.1}.
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DR EMBL; CBBI010000064; CDA19413.1; -; Genomic_DNA.
DR AlphaFoldDB; R5XWC3; -.
DR STRING; 1262959.BN680_00466; -.
DR Proteomes; UP000018248; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd10912; PIN_YacP-like; 1.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR010298; YacP-like.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF05991; NYN_YacP; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Elongation factor {ECO:0000313|EMBL:CDA19413.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 1..225
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 849 AA; 95379 MW; C44A2D3D6E990F41 CRC64;
MKKIVAGILA HVDAGKTTLA EAMLYRTGKL RKIGRVDHGD MALDTHTLER ERGITIFASQ
AVFSTDKIEV TLLDTPGHVD FSSETERTLS VLDYAILVIS GLDGVQSHTM TLWKLLKLYN
VPTFVFVTKM DFARKSREEI IENLNSELDG EFVDFGDEEA VSENMALCSE SLMEKYLSGE
EIDEKEIAEV IKLRKIFPCF FGSGLKLDGI DKFIKALEEY TIQPEYPEAF GAKVFKISHD
SQGVRLTHIK VTGGSVKVRE MIGDEKISGI RIYSGAKFTT ADEVGSGEIC ALTGLDKTHN
GQGLGFEDAG EKPMLEPVMN YRVVLPDGCD ADTLLPKLRE LEEEDPQLHV TWNSHLKEIH
VGLMGEVQAE ILKSIVAERF GVKIDIDSGR VMYKETIENT VEGVGHYEPL RHYAEVHLIM
EPLPRGAGLI FKTDCSEDTL DRNWQRLILM HLGEKQHLGV LTGSPITDMK ITLAAGRAHI
KHTEGGDFRQ ATYRAVRQGL MQAKSKLLEP YFSFRLEVPS EQIGRAINDI RMKSGSFESP
EESGGISVLS GRAPVTELNG YASEVAAYTG GRGRLYCESA GYDDCHNAEK VIAELAYDPE
ADLENTPDSV FCAHGGGFGV KWNKVGEYMH LESCLEKEKP YTPPVNRRNL HIDDKELEAI
MEREFGKPKY ELYRPMAKKN DENQTDFELT ERKSYVLVDG YNVIFAWDEL KRLADTDLGA
ARERLMEILC NYSAYTKNNV VLVFDAYKVP GNTGERFDFH NIHVVYTKER ELGDVYIEKL
ISEIGKNDRV RVVTSDNLIQ LSAVRFGVLR MSAAEFEREV DSVHAKIGKF LDEIREKNSK
TKIDEISKI
//
