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Database: UniProt
Entry: R5Z6K4_9ACTN
LinkDB: R5Z6K4_9ACTN
Original site: R5Z6K4_9ACTN 
ID   R5Z6K4_9ACTN            Unreviewed;       431 AA.
AC   R5Z6K4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   05-JUL-2017, entry version 25.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   ORFNames=BN511_00635 {ECO:0000313|EMBL:CDA35343.1};
OS   Collinsella sp. CAG:166.
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   Coriobacteriaceae; Collinsella; environmental samples.
OX   NCBI_TaxID=1262850 {ECO:0000313|EMBL:CDA35343.1, ECO:0000313|Proteomes:UP000018358};
RN   [1] {ECO:0000313|EMBL:CDA35343.1, ECO:0000313|Proteomes:UP000018358}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:166 {ECO:0000313|Proteomes:UP000018358};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDA35343.1}.
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DR   EMBL; CBBR010000062; CDA35343.1; -; Genomic_DNA.
DR   Proteomes; UP000018358; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018358};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018358}.
FT   DOMAIN      103    231       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      337    406       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   431 AA;  47574 MW;  EE690C003571028B CRC64;
     MPIAHDAAAG ADSGIAIKNT LSADDFRRMM NQMKGGAPTK STQAATPASP MPAPTVPAEQ
     NTDGAPLAAN SKFTFENFVY GPENSHAYRS ALKFAALADE RGTCTSLFIY GKSGLGKTHL
     LLAIKNELAE KSPEIKVKYA NSQAYLDDLM TEFDRQKKSN APIMQAYHGV DVLIIDDIQN
     IIGKRASVDY FFQLMDEFIR NNKKVVIAAD RAPKDLSMDE RLTSRFNAGM LCLVAEPSYE
     MKYKILQRYY ENTIVAAPEA GDDSLLAAYG GDGGHLTDEH FKHMAEVSGT NIRELESFCE
     RCAGEAGDRE REGGELTFDD IDAIASQYFD TSAKKINVQT VQSVIEEQYG VTHEELIGPR
     RNANIAKARH IAIYLAIEMC EMTTTAVGAE FGNRNHSTVS TSYKKVQKMI QEDRTVTEDL
     KSLRDKITLR S
//
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