ID R6D2V9_9BACE Unreviewed; 768 AA.
AC R6D2V9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=BN772_01459 {ECO:0000313|EMBL:CDA82973.1};
OS Bacteroides sp. CAG:754.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1262750 {ECO:0000313|EMBL:CDA82973.1, ECO:0000313|Proteomes:UP000017906};
RN [1] {ECO:0000313|EMBL:CDA82973.1, ECO:0000313|Proteomes:UP000017906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:754 {ECO:0000313|Proteomes:UP000017906};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA82973.1}.
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DR EMBL; CBCP010000047; CDA82973.1; -; Genomic_DNA.
DR AlphaFoldDB; R6D2V9; -.
DR Proteomes; UP000017906; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 3.90.182.10; Toxin - Anthrax Protective Antigen;domain 1; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR026876; Fn3_assoc_repeat.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF13287; Fn3_assoc; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR Pfam; PF07691; PA14; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SMART; SM00758; PA14; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR PROSITE; PS51820; PA14; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000017906};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..768
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004415134"
FT DOMAIN 630..764
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT ACT_SITE 349
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 768 AA; 87003 MW; F7E78B96CD0A94D9 CRC64;
MFKQLSTSLL IVSACVFSAC TPAVKQEIAI LPTPVSLTEQ SGAFVFKDEM KIGVSDQSLF
PAVGYLQEIL RNVVSSSVEV TADKNQVDVY FQLGNTNGKS GSYKLQSTPE FIQVEANDYS
GIISAITTIR QLLPAEIEIQ GVKQTYSIPA VQIEDAPRFE WRGFMLDASR HFWNKDEVKH
VLDLMSLYKL NKFHWHLTDD QGWRIEIEKY PLLTEKGAWR KFNTHDRTCM ARVIEEDNTD
FLIPENKIRI VEGDTLYGGY YTHDDIKEIV AYAAQRGIDV IPEVDMPGHF LAAISQYPDL
ACDGLIGWGE TFSSPICPGK DATLEFCRNV FKEVFELFPY EYVHMGGDEV EKNNWKKCPR
CQKRIRTEGL GSVEELQAWF VRDMEKFFQA NGKKLVGWDE VVKDGLSSDA AITWWRSWAK
EALPTATAQK QKVIACPNEY FYFDYAQDQN SVKKILAFDP YADDRLSQEQ KEYIWGVQAN
LWAEWIPTMK RIEYLIVPRM IALSEIAWAE PAAKPELDEF YRQLVPQFKR MDIMRVNYRI
PDLQGFYKVN AFIDDATVNL TCPLPGTEIR YTTDGSMPTR KSSLYNGSLK IKETTDFAFR
TFRPDGSPSD VARTRYVKAP YAEAVTAPAS LQPGLKAVWH NFRGNLCVDI DAAPVRGEYV
VESVSIPEEV KGDIGLVITG YLEVPADGIY TFALLSDDGS TLMLDGELLG DNDGAHSPVE
IIVQKALKAG LHPMEVRYFD CNGGVLQLEL VNDKGEKEVL PKEWLKHE
//
