ID R6D688_9BACE Unreviewed; 958 AA.
AC R6D688;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN ORFNames=BN772_01724 {ECO:0000313|EMBL:CDA83245.1};
OS Bacteroides sp. CAG:754.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1262750 {ECO:0000313|EMBL:CDA83245.1, ECO:0000313|Proteomes:UP000017906};
RN [1] {ECO:0000313|EMBL:CDA83245.1, ECO:0000313|Proteomes:UP000017906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:754 {ECO:0000313|Proteomes:UP000017906};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA83245.1}.
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DR EMBL; CBCP010000069; CDA83245.1; -; Genomic_DNA.
DR AlphaFoldDB; R6D688; -.
DR Proteomes; UP000017906; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000017906}.
FT DOMAIN 26..204
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 222..328
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
SQ SEQUENCE 958 AA; 109163 MW; 2686B2E5921EE6F8 CRC64;
MKRLLVSIAI VFVTLLTAMG QNHSFSLSGK WNFQIDREDI GVREQWFKKS LDDSINLPGS
MPEKLKGDEV TARTQWTGSL YDSSYYFNPY MEKYRIEGQV KLPFFLTPDK HYVGVAWYQK
KVTIPSNWKG ERISLFLERP HIETTVWVNQ KELGMQNSLC VPHVYDLTSA VSPGKTCLIT
IRIDNRIKEI NVGPDSHSIT DQTQGNWNGI VGRIELQATP KVHFENIQVY PDLSNQKALV
RMNVQSTSSA KGEITLSAES FNTDIRHKVA PAQQSFSIRQ GDNAVEMELP MGKDFLTWDE
FNPALYKLTA TLSNGKQTDT KQVQFGMRDF KIEGKWFYVN GRKTMLRGTV ENCDFPLTGY
APMDVASWER IFRICRSYGL NHMRFHSFCP PEAAFIAADL VGFYLQPEGP SWPNHGPRLG
NGQPIDKYLM NETIALTKEY GNYASYCMLA CGNEPSGRWV AWVSKFVDYW KATDPRHVYT
GASVGNSWQW QPHNEFHVKA GARGLSWAGA CPESMSDYRA RIDTVKQPYV SHETGQWCVF
PNFNEIRKYT GVNKAKNFEI FRDILNDNHM GSQSYDFMMA SGKLQALCYK HEIEKTLRTP
DYAGFQLLAL NDYSGQGTAL VGVLDVFFEE KGYINAEQFR RFCSPTVPLA RIPKFVYANN
ETFHADIEVS HFGAAPLQEA KTVYTIKDKF GKVYAHGTVG THNIPVGNLC SLGSVDMDLA
EITTPQKLNL EVRIEGSDAV NDWDFWVYPA QVELTQGDVY TTDTLDAKAL SVLQEGGNVL
ITAAGKIQYG KEVKQYFTPV FWNTSWFKMR PPHTTGIFVN EYHPLFRQFP TEYHSNLQWW
ELLNKAQVMQ FTDFPAEFQP TIQSIDTWFI SRKIGMLFEA KVLNGRLMMT SMDITSQPEK
RIVARQMHKA VLDYMNSDAF RPTTTVSTEQ IQALFTKVAG DVKSYTKDSP DELKPKIN
//
