ID R6DNP0_9FIRM Unreviewed; 758 AA.
AC R6DNP0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Acyl-coenzyme A synthetases/AMP-(Fatty) acid ligases {ECO:0000313|EMBL:CDA89220.1};
GN ORFNames=BN710_00381 {ECO:0000313|EMBL:CDA89220.1};
OS Ruminococcus sp. CAG:563.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1262961 {ECO:0000313|EMBL:CDA89220.1, ECO:0000313|Proteomes:UP000018082};
RN [1] {ECO:0000313|EMBL:CDA89220.1, ECO:0000313|Proteomes:UP000018082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:563 {ECO:0000313|Proteomes:UP000018082};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA89220.1}.
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DR EMBL; CBCR010000036; CDA89220.1; -; Genomic_DNA.
DR AlphaFoldDB; R6DNP0; -.
DR STRING; 1262961.BN710_00381; -.
DR Proteomes; UP000018082; Unassembled WGS sequence.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd02209; cupin_XRE_C; 1.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR013096; Cupin_2.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF07883; Cupin_2; 1.
DR Pfam; PF12844; HTH_19; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CDA89220.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018082}.
FT DOMAIN 18..72
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
SQ SEQUENCE 758 AA; 85486 MW; A0150D54C433C690 CRC64;
MKEMTGLNFK INEMAQRIKE LREIVGFTPA DMAEKTDMTI EDYIACERGE KDLTFAFLYR
CAIAFNVDVN DIIEGKSPVL ASYTVTRSGE GLEIDHAHGM EYYNLAAAFK NKICEPLFVR
CDPNEGSDDI ALTTHEGQEL DIVVSGTLRV QVGNHVEILH PGDTIYFDSS TPHGMIAVDK
EETTFYALVF NPAGEVVTPK NTIDDESPKR SGTGKRIYHN FIHPKEDENG KVLSLSYENE
DKFNFAFDIV DGLGKKLPDK LAMLHIDKNK NERRFSFKDM MEYSAQTANY FKSLGIKKGD
RVMIVLKRHY QFWFSILALH KIGAIAIPAT HLLQEHDLDY RFNAAGVSAI ICTSDDDTAH
QVDLAAKNSP TLKTKIIVGE PREGWHDFND EVKLFSKEFE RTEDSACGND KMLMFFTSGT
TGYPKIATHN FKYPLGHFVT ANYWHCVNPD GLHLTISDTG WAKALWGKLY GQWLCEAGIF
VYDFDRFHAS DILPMFKKYN ITTFCAPPTM YRMMIKEDLT KYDLSSIEHA TIAGEALNPE
VFRQLNKLTG LKVMEGFGQS ETTLVVGNLF GSEHKLGSMG KPVPTFDVDI VDPDGKSVGV
GQEGEIVIKA ERDKVPCGLF IGYYGDEEKT SECWHDGLYH TGDVAWRDED GFYWYVGRID
DVIKSSGYRI GPFEIENVIM ELPYVLECGV SAAPDEVRGQ VVKASIVLTK GTEPTEELKK
EIQTYVKEHT APYKYPRIVV FKDELPKTTS GKIIRNKL
//
