ID R6DUP9_9FIRM Unreviewed; 643 AA.
AC R6DUP9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=3D-(3 5/4)-trihydroxycyclohexane-1 2-dione hydrolase {ECO:0000313|EMBL:CDA91365.1};
GN ORFNames=BN710_01180 {ECO:0000313|EMBL:CDA91365.1};
OS Ruminococcus sp. CAG:563.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1262961 {ECO:0000313|EMBL:CDA91365.1, ECO:0000313|Proteomes:UP000018082};
RN [1] {ECO:0000313|EMBL:CDA91365.1, ECO:0000313|Proteomes:UP000018082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:563 {ECO:0000313|Proteomes:UP000018082};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA91365.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CBCR010000085; CDA91365.1; -; Genomic_DNA.
DR AlphaFoldDB; R6DUP9; -.
DR STRING; 1262961.BN710_01180; -.
DR Proteomes; UP000018082; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CDA91365.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018082};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 8..138
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 223..355
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 439..598
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 643 AA; 69948 MW; 0EB9519A5CDA7645 CRC64;
MKTIRLTAGE AIVKYLDNQY VAIEQDGKLV ESKFVELFYA IFGHGCVLGV GEALSQAEHS
IKVMQGRNEQ GMAQAATAYA KMNNRLKIIP CMSSIGPGAA NMVTAAATAT VNNIPLLLFM
GDTFASRQPD PVLQQVEQLH DGTCTTNDAF RAVTRYFDRI TRPEMVMTAL TNAMRVLTDP
AHTGAAAIAL CQDVQGESFD YPVEFFRKRV HFIPRQIPCD YEVKAVAEEI KKSKKPLVIV
GGGVRYSFAG EQVKAFCEKH NIPFSETQAG KSAIESSHYL NVGGIGVTGN SSANVLAGDA
DLIIGIGTKF SDFTTSSKWL YADTQVVTIN ASAFHGGKLD SIKMVADAKE GITALEKYLD
GYKSAYTTEI ADAKADWDKE MARLAATHYG EGYTPEIPNH MPDAVESFIK ATGGVITQTA
ALSLIRKLIP ADAVAVGAAG SLPGCMQRMW TTDKLYSYNM EYGYSCMGYE IAGAFGSKLA
CPDQEVYAFT GDGSYNMLHS EMLTALQEGK KINVMLFDNA SFGCINNLQM GQGVNSLCTE
ARYRDGDKPI REGEFMNIDY AACARGYGYV AYTAKTMDEL EAAVLDSLKQ TKPVLIDIKV
LPKSMTDGYG GWWNVGCSDI PRTEKGKEAL AERTQKLSEA KKY
//