ID   R6FUQ5_9FIRM            Unreviewed;      1420 AA.
AC   R6FUQ5;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Putative CoA-substrate-specific enzyme activase {ECO:0000313|EMBL:CDB12741.1};
GN   ORFNames=BN525_00666 {ECO:0000313|EMBL:CDB12741.1};
OS   Eubacterium sp. CAG:192.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1262883 {ECO:0000313|EMBL:CDB12741.1, ECO:0000313|Proteomes:UP000017943};
RN   [1] {ECO:0000313|EMBL:CDB12741.1, ECO:0000313|Proteomes:UP000017943}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:192 {ECO:0000313|Proteomes:UP000017943};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB12741.1}.
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DR   EMBL; CBDB010000139; CDB12741.1; -; Genomic_DNA.
DR   STRING; 1262883.BN525_00666; -.
DR   Proteomes; UP000017943; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014}.
FT   DOMAIN          9..263
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          329..583
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          678..897
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   1420 AA;  157805 MW;  57DFB481381F9B00 CRC64;
     MNENANYSLG IDIGSTTVKI AILDQDXILD QDNNLVFSDY ERHYANIQET LALLLDKARK
     QLGSIELSPM ITGSGGLALS EHLKVPFVQE VVAVSTALED YAPQTDVAIE LGGEDAKIIY
     FTNGIEQRMN GICAGGTGSF IDQMASLLQT DASGLNEYAK NYQEIYPIAA RCGVFAKTDI
     QPLINEGATK EDLAASIFQA VVNQTISGLA CGKPIRGTVA FLGGPLHFLP ELKNAFIRTL
     KLDDEHVVAP EHSHLFAATG AALNHKENIK VDIDDLYEQL SHGVQMSMEI KRLEPLFQNQ
     EAYDKFTERH NKAKVKKGDL ASYSGNCYLG IDSGSTTTKA ALVGEDGTLL YSFYSGNNGN
     PLKTIIDSIK DIYAKLPKDA HIVRSCSTGY GEALIKNALL LDEGEVETVA HYNAAAFFEP
     QVDCILDIGG QDMKCIKIKN NSVDSVQLNE ACSSGCGSFI ETFAKSLNYS VEDFAKEALF
     ASNPTDLGTR CTVFMNSNVK QAQKEGASVA DISAGLAYSV IKNALYKVIK ISDARDLGRK
     IVVQGGTFYN DAVLRSLEKV AHIHAIRPDI AGIMGAFGAA LIARDRYKGE PTTMLNLKQL
     EEFTYTTSMT RCKGCTNSCL LTINKFSDGR RFISGNRCEK GIGGQKNKDN IPNLFEYKLK
     RMFDYEPLSP DNAPRGIVGI PRVLNMYENF PFWATFFKKL GYSVVLSPES SHKLYEMGIE
     SIPSESECYP AKLVHGHITW LIKQGVKFIF YPCIPYERNE TPDANNHYNC PIVTSYAENI
     KNNVEELEDP SMKFMNPFMA LTNEETITSR LVEEFGNEFG INAGEVKEAA HLAWEELLNS
     RNDMAKKGEE TLKYMEENGK RGIVLAGRPY HVDPEINHGI PEMINSYGLA VLTEDSISHL
     AEVERPLIVS DQWMYHSRLY RAANYVKTRD DLDLVQLNSF GCGLDAVTTD CVSDILTKSG
     KIYTVLKIDE VNNLGAARIR IRSLLAAIRV RSENHFERTI QPSSINKVEF TKQMYEDKYT
     ILTPQMSPIH FKMLQAALNS CGYNFEVMDS KPSCVDVGLK YVNNDACYPS LIVVGQIMEA
     LLSGKYDLNK TAVIITQTGG GCRATNYIGF IRRALEKAGM SHIPVLSLSL QGLEKNSGFK
     ITPKFAIKAV EAAMYGDLFM RVVYRTRPYE VNEGETDALH KKWEYKLCKE LADNKFGIRR
     FKKNMKKIVK EFDAIPVKDI KKPRVGIVGE ILVKFSPTAN NNLVELLESE GAEAVMPDLV
     DFFLYGFRNA TFKYENLGFD KKSVRINNLG IKAIEWFRNS AKKALIESKH FTPTSDIWEM
     SEMAEKVVSI GNQTGEGWFL TGEMLHLLHD GVPNIICTQP FACLPNHIVG KGVIKKLRAM
     NPDANIVAVD YDPGASEVNQ LNRIKLMLAT ANKRLNQEKK
//