ID R6HJI5_9ACTN Unreviewed; 918 AA.
AC R6HJI5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Penicillin-binding protein transpeptidase domain-containing protein {ECO:0000259|Pfam:PF00905};
GN ORFNames=BN534_00316 {ECO:0000313|EMBL:CDB34204.1};
OS Eggerthella sp. CAG:209.
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Eggerthella.
OX NCBI_TaxID=1262875 {ECO:0000313|EMBL:CDB34204.1, ECO:0000313|Proteomes:UP000018042};
RN [1] {ECO:0000313|EMBL:CDB34204.1, ECO:0000313|Proteomes:UP000018042}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:209 {ECO:0000313|Proteomes:UP000018042};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB34204.1}.
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DR EMBL; CBDM010000235; CDB34204.1; -; Genomic_DNA.
DR AlphaFoldDB; R6HJI5; -.
DR Proteomes; UP000018042; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001182; FtsW/RodA.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR Pfam; PF01098; FTSW_RODA_SPOVE; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018042};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 597..902
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 918 AA; 96693 MW; BA11EE37518FAB88 CRC64;
MTRRNTELML LCIAAPLVIL LFAMVALNEG NRVTLDNLTV PLSMFATFVV AHLAIRKLAP
GADPAILPLS FALSGIGIAF ITRLAPDLAM KQVGWLFLGV VFMVLVLAFV KNLDKLGSYK
YTIMIAGILL LMSPMLPVIG NEIYGSRIWL SIGGFSIQPG ELAKICIVIF LAAYLAQNRE
MLSVFNHKLG PFRVPDMRAL VPVIIMWAVA LLVIVFEKDL GSALVLFFVF VTMLYVATGK
HAYIVISLLM VSVGFVFVYF LFSHVQVRVD TWLNPFADPT NTGYQLVQSI FSIADGGLFG
VGIGNGMAEQ IPIVESDFIF SAIAEEAGLL GAAGVLLLYL CFAIRGILIS VRAKSDVSSF
MAVGFTAVIV LQAFIIVGGV TRLIPLTGLT LPFVSQGGSS LLASFIILGF LLRASDQGTG
LGTEMASGTG VVSLNGALGR VSLGKRLTGT MIVFSALFAL LVANLTMIMV IQADEYKNMP
INNHTLAKES KTERGAITTY DNVLLAHSVL QDDGSYKREY PAGNLAAHVV GYASDTYGTS
GIEASCNDTL KGESNYASWI DVLNSYSGAG TAGNDVKLTI NSTIQKAAQD SLKGYKGACV
AIDPKTGAVL ALASSPTYDA DDVDNILSSG GDSSALYNRA TQALYSPGST FKIVTLTTAL
ADNVATESTQ YDSPSTLDIG GGKVTNFNNS SYGTITLQRA TELSANTVFA QLGDQIGADG
LVSSSEKFGF NNALNFDLPL AKSLMPDPNE MTEWETAWAA AGEPVGEHAS PAGPQATVLQ
MALVGCAIAN NGTIMQPYLV DSVNNSDGKN SYRATPSTMS NVCSSSVAKR VRTVLEGVVN
NGTGKAAAIS GVQIAGKTGT AETGKEKDDR WFVGMGPSDD CSVVVAVVLE EAGESLSGGA
AGRAQGVLRA ALEVQGNL
//