ID R6HMP0_9FIRM Unreviewed; 1109 AA.
AC R6HMP0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN574_01549 {ECO:0000313|EMBL:CDB35449.1};
OS Phascolarctobacterium sp. CAG:266.
OC Bacteria; Bacillota; Negativicutes; Acidaminococcales; Acidaminococcaceae;
OC Phascolarctobacterium.
OX NCBI_TaxID=1262915 {ECO:0000313|EMBL:CDB35449.1, ECO:0000313|Proteomes:UP000014925};
RN [1] {ECO:0000313|EMBL:CDB35449.1, ECO:0000313|Proteomes:UP000014925}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:266 {ECO:0000313|Proteomes:UP000014925};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB35449.1}.
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DR EMBL; CBDN010000098; CDB35449.1; -; Genomic_DNA.
DR AlphaFoldDB; R6HMP0; -.
DR STRING; 1262915.BN574_01549; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_1_3_9; -.
DR Proteomes; UP000014925; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000014925}.
FT DOMAIN 2..431
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 450..728
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT COILED 234..297
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 770..797
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 23..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1109 AA; 124782 MW; 95AA6F49FA9402C5 CRC64;
MFNFTENQAA AINTLSCNVS VSAGAGSGKT RVLVERFINI LAQGIKNPQQ AVQPKEILAI
TFTRKAAAEM KERIRKRLYE LEKEDAVNKE FWHNHRQRFD QARISTIHGF CNGILKENSV
ETGLDPSFNV AEENDMQEFW ETNITAFIKK AIAENDSGLK ELIRNYGIDG VKSQLLSIYS
IDDEVLKIEN PAEPYKKSAD CAPELQAELT ALVDELIAGM DGVIKKTTKQ YPKLQNLKEN
RHLVIEAIQK YETEESRAVL NQYIGVLTMQ AKDKAVVAEA KEALKKLYQA VIDARAAELV
TVWHNVLRSC RKFVLAKQEE LNLIGFDDLE SLALKLLLDS QETRHKYQQN FKYIMVDEFQ
DTNERQREII YLLCGDDKDS LNGNKLFVVG DPKQSIYRFR GADVNVFARV RRDIAAKKGK
NIVLDDNFRT VDKILDFCNA TFPDLLGLDE TQDVFFEALR ANRSGTLLPE LIVIKHDEQT
VQMDAREAEA AFIAQKIKNL HDEEGILYSD IVILLRAMTK VDYYENALNC CGIPCNVVDG
KGFYGRQEII DFINLLTVCA DSRRNLELAG VLRSPYFAVD DETLTALFFE LQDNADKYES
LWQILQSGTY PEYLAETEKS KLKRCSGVLK QIYDASMSLP LTDLFSFIEQ ILNLNAVTAA
QPGGEEKNAN LKKLFALAAE FCLHRQGGLR EYLDNIKRLR ALNAREAAAV AGNAQEAVKI
MTIHKSKGLE FPTVILPALD TGVGGVSTQI NFNKNTGLGI KVDVNGNLQE SSVFKEIKAL
NSELDKAEKE RQFYVAATRA KDRLILSGVT KTKGDKGTWF KNLENILSGY EGMIFTDVDA
AEILPQAMQA EEDAGSLIAE DVIANTLPLP EYGKAWQQSF SASSLQQYNI CQRSFYYHYI
LQMPPVEPQL NGENAIDART FGTLVHEALE KYAGNVKKAL MQAAYDNNLQ DYDLSEAETL
LTNYLQSSLY PGLNIKQLHE NGFTLPVLAK YGINAQCYGF IDNIIYNSDG SLSIIDYKTG
HVPDALPKGY KYQLALYKLA AEEMFNLPVK SSELHFLRGC VNFELPADFN PEEIAAELQS
IFAKTDEREF TCSTAYCHSC PYAYFCKKI
//
