ID R6J2Y2_9CLOT Unreviewed; 498 AA.
AC R6J2Y2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=L-threonine synthase {ECO:0000313|EMBL:CDB52066.1};
GN ORFNames=BN539_00298 {ECO:0000313|EMBL:CDB52066.1};
OS Clostridium sp. CAG:217.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262779 {ECO:0000313|EMBL:CDB52066.1, ECO:0000313|Proteomes:UP000018364};
RN [1] {ECO:0000313|EMBL:CDB52066.1, ECO:0000313|Proteomes:UP000018364}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:217 {ECO:0000313|Proteomes:UP000018364};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB52066.1}.
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DR EMBL; CBDU010000104; CDB52066.1; -; Genomic_DNA.
DR AlphaFoldDB; R6J2Y2; -.
DR STRING; 1262779.BN539_00298; -.
DR Proteomes; UP000018364; Unassembled WGS sequence.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF00291; PALP; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000018364}.
FT DOMAIN 3..79
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT DOMAIN 105..362
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT MOD_RES 113
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 498 AA; 54917 MW; 3250B2F1B47E230C CRC64;
MLYTSTRNNK IRVTAAQAIA QGISEEGGLF VPVELPHFSM DTVREMMEMS YIDRAKTVLR
TFLTDFSDEE LNYCVEGAYR ADKFSSPAVA PTVNIGGKEN ILELWHGPTC AFKDMALQLL
PYLMTVSAKK TAEGKTIVIL VATSGDTGKA ALEGFKDVDK TKILVFYPVD GVSPMQKLQM
TTQEGENVAV CAIHGNFDDA QSAVKSIFTN DEIKAELAKK NMMFSSANSI NWGRLVPQIV
YYFSAYADLC KMGQLQVGEP MNVVVPTGNF GNILAGYYAK HMGLPIQTMV CASNTNNVLT
DFLKTGTYDR NRDFYATTSP SMDILISSNL ERLLYHMSGE SDAAVRGWMT QLAENGKYTV
EPEVMAKIQN EFAAGYCDEA AVADTIHKTY TDQNYLCDTH TAVAVKVYRD YVAQTGDDLP
TVIDSTASPY KFSKSVLTAV LEGNTPQLDE FDMVEELHRV TGAAVPAPLA ALKDKAVRFT
QVCDRENMSQ MVFQLLNL
//
