ID R6JD54_9BACT Unreviewed; 756 AA.
AC R6JD54;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Glycoside hydrolase family 20 catalytic core {ECO:0000313|EMBL:CDB56544.1};
GN ORFNames=BN502_00073 {ECO:0000313|EMBL:CDB56544.1};
OS Akkermansia muciniphila CAG:154.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=1263034 {ECO:0000313|EMBL:CDB56544.1, ECO:0000313|Proteomes:UP000018106};
RN [1] {ECO:0000313|EMBL:CDB56544.1, ECO:0000313|Proteomes:UP000018106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:154 {ECO:0000313|Proteomes:UP000018106};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB56544.1}.
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DR EMBL; CBDW010000161; CDB56544.1; -; Genomic_DNA.
DR AlphaFoldDB; R6JD54; -.
DR Proteomes; UP000018106; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06564; GH20_DspB_LnbB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR43678:SF1; BETA-N-ACETYLHEXOSAMINIDASE; 1.
DR PANTHER; PTHR43678; PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CDB56544.1};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..756
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004410384"
FT DOMAIN 110..228
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 232..414
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT REGION 588..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 413
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 756 AA; 83771 MW; CBCC8396F55A6C54 CRC64;
MKKNLFLMIA VLAASPVMGQ DAKQIADSLS IPPVKAGAKQ LPMPSVSGAQ IKLLGADYEQ
LVNSKGKIAP VISDTPVNVS FKVTKDGKEA VSKDYEIMLQ APQAAQGNPK PRIIPEILQW
KGGQGEYKLG NTVTIACPDK ELGKLFAADM EDVLGKKVKL VAPGAKADIS LSLLKGGNLG
REGYRLQIAR DGVRLGAAAP TGLFWGTRTL LQMLRQTPGS VPCGTAVDFP RYQLRGFMLD
VARTPYPLSY LKDVIRTMAW YKMNDLHLVI NNNYIFHEHY VDNGHDPFKE SYAAFRLESK
MKGKDGTPLT AKDLFYTKKE FADLVSYARK YGVNIVPEFD TPGHALSFTR LRPDLIYKGP
MNHEKRRCEM LDAANPETID LVSKVFDEYM LKDPKLGRPV FADCGVVHVG ADEFYGDKED
YRHFANAVLS HALKRGYTPR IWGSLSAKPG KTPVVSKGVQ MNLWSTGWMK AWEAVNQGYD
VINTNDGALY IVPFAGYYRM DRNHKGLYNN WIPNRIGNET LPSGHPQLLG GTFAVWNDET
DIMHTGYAPY DIWGIISGSM DVLSQKLWGT AKAPDTFEQH RELVSSIGNA PRTNPLHKWK
DSQPFTVKPS SLPQKLDKPA LGPNYRLTME LELTAAPEGK EQVLLAAPEG ELLAVMKDGT
VGFRRDDSLE FSFGAKLPVG KKVKVEIVGE PEKTSLLLDG EPAGTAVLKN FSDKSKDFSD
KFKHRPKVHR STFILPLKEL GSSFQGKVFH MNVQPL
//
