ID R6JXB0_9BACT Unreviewed; 549 AA.
AC R6JXB0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN ORFNames=BN502_01013 {ECO:0000313|EMBL:CDB54692.1};
OS Akkermansia muciniphila CAG:154.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=1263034 {ECO:0000313|EMBL:CDB54692.1, ECO:0000313|Proteomes:UP000018106};
RN [1] {ECO:0000313|EMBL:CDB54692.1, ECO:0000313|Proteomes:UP000018106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:154 {ECO:0000313|Proteomes:UP000018106};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB54692.1}.
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DR EMBL; CBDW010000023; CDB54692.1; -; Genomic_DNA.
DR AlphaFoldDB; R6JXB0; -.
DR Proteomes; UP000018106; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06563; GH20_chitobiase-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..549
FT /note="beta-N-acetylhexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004422482"
FT DOMAIN 30..146
FT /note="Beta-hexosaminidase bacterial type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02838"
FT DOMAIN 150..502
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT REGION 526..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 327
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ SEQUENCE 549 AA; 61806 MW; 1BC582F32178877C CRC64;
MISKCIFPAT VFSLFSLCWG APSAPVLEAP HIIPLPAAMR VQTGESGFSL KNGVRLPEKN
PLSRQAERIF RDNGINTALV KNNADIIFTE DASLSREGYR LAVTPDSISI ASGSVNGTLY
ALQSLVQSIA ADKNGAPALP RMDVKDQPRF SWRGLMVDSC RHMMPVRDIK KVLDLMERYK
FNTLHWHLTD DQGWRLPIAK YPRLTTVGGA RAQSPVIGNR NKGDGIPYSG HYTADEIRDV
VRYARDRGIT VIPEVEMPGH ASAAIAAYPE LGNTDIPGYA PKVQETWGVH SYTFSPTEKT
FRFLEDVIDE ICALFPDSPY IHIGGDEAPK NQWKQSPTAQ RVMKDNGLAN EHELQSYFIR
RVEKIINSRG KRLIGWDEIQ EGGLSPTATM MVWRSQMPHI AAQTLARGND IVMTPNSHLY
FDYDQGPGKP AAPEYETINN NQLTWQHVYG LEPVPQGTPR EREKQVLGCQ ANIWTEYIPN
LPKWEYHVFP RALALAEVAW TPQELKNEKD FRKRLDRQLP FLDARGVNYK RPDNGAPAQP
EAVITRERR
//
