ID R6KG64_9FIRM Unreviewed; 494 AA.
AC R6KG64;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Transcriptional regulator with HTH domain and aminotransferase domain {ECO:0000313|EMBL:CDB69001.1};
GN ORFNames=BN564_00458 {ECO:0000313|EMBL:CDB69001.1};
OS Eubacterium sp. CAG:252.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1262887 {ECO:0000313|EMBL:CDB69001.1, ECO:0000313|Proteomes:UP000017970};
RN [1] {ECO:0000313|EMBL:CDB69001.1, ECO:0000313|Proteomes:UP000017970}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:252 {ECO:0000313|Proteomes:UP000017970};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB69001.1}.
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DR EMBL; CBEA010000151; CDB69001.1; -; Genomic_DNA.
DR AlphaFoldDB; R6KG64; -.
DR Proteomes; UP000017970; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:CDB69001.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:CDB69001.1}.
FT DOMAIN 12..80
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
FT REGION 95..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 55949 MW; D554DED3A352D0E1 CRC64;
MLTYSFNNRN GRSLYEYLYI CIKEDIISGK LSPDTKLPSK RDFAKNHGIS VVTVENAYGQ
LLAEGYIYSL PKKGFYVSDI NNNISQSSYS VIKIPDTNNT ENGSKTNSGV SDTDNNSDNP
VYIKPSAPAE FINLVSSHTP HDNFPFSIWA KLMRHVLTYE GDDTLNVPPT GGVMQLRSAI
AHHLYEFRGI TVSPEQIIIG AGTEYLYGLI VQLLGRDLSY GLENPSSKKI VNIYRSLDVN
VNYLDMDDEG VIPDCAGLNN SQIIQISPSH HFPTGIVTSI SRRYGLLQWA NQSPDRYIIE
DDYDSEFRLQ GKPIPSLFSI DATDKVIYFN TFTKSLASTI RISYMVLPQP LLKCFKSKLG
FYSCTVSNFE QYTLAHFIDE GYLDKHINRM RNHFRDIRDE LIGKLMNSSI KDKLHIYEEN
SGLHFLLCYD TAVSDEELKK RAYDKGLLIS FLSDYIAHSS YNRTAYEHIA IVNYSGITAA
DVEKTARLLI DIYM
//
