ID   R6KML6_9BACE            Unreviewed;       621 AA.
AC   R6KML6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:CDB71206.1};
GN   ORFNames=BN506_00271 {ECO:0000313|EMBL:CDB71206.1};
OS   Bacteroides cellulosilyticus CAG:158.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=1263038 {ECO:0000313|EMBL:CDB71206.1, ECO:0000313|Proteomes:UP000018191};
RN   [1] {ECO:0000313|EMBL:CDB71206.1, ECO:0000313|Proteomes:UP000018191}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:158 {ECO:0000313|Proteomes:UP000018191};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB71206.1}.
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DR   EMBL; CBEB010000190; CDB71206.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6KML6; -.
DR   Proteomes; UP000018191; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   InterPro; IPR017790; Penicillin-binding_protein_2.
DR   NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018191};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          54..222
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          261..579
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   621 AA;  69587 MW;  8BB5577ED0E62EEE CRC64;
     MAKDYTLEKR KFVIGGVAIV IVIIYIMRLF VLQIMTDTYK KNADSNAFLN KIQYPSRGAI
     YDRNGKLLVF NQPAYDITFV PREVTELDTL DFCRTLNITK EQLLKRMKDV KNRWMNPGYS
     RYTHQVFMTQ LSAEECGVFQ EKLFKFPGFY IQRRTIRQYT YNSAGHALGD IGEVSMRDIE
     ADDYYIRGDY VGKQGIEKSY EKYLRGEKGV EVLLRDAHGR IQGHYMDGKL DRPSIPGKNL
     KLGLDIDLQM LGERLMKNKI GAIVAIEPET GEILCLVSAP NFDPHLMIGR QRGKNHNMLQ
     RDKQKPLLNR AIMGVYPPGS TFKTAQALTF LQEGIIQPST SFPCSHGFIY GGLRVGCHGH
     GSPLPLIPAI ATSCNAYFCW GLYRMFGDKK YGSPQNALTV WKDHMVSQGF GYKLGTDLPG
     EKRGFIPNAG VYDKAYRGSW NGLTVISISI GQGEVLSTPL QMANLAATIA NRGYFVTPHI
     VKDIQDAELD STYRERRYTS IDRSYYEEIV EGMRAAVTGV TGSATCRIAG TILPGVEVCG
     KTGTAQNRGH DHSAFIGFAP MDKPKIAIAV YVENGGWGAT YGVPYGALMM EQYLNGKLSP
     ASEERAEEMS NRVIMYGDEE R
//