ID   R6LM74_9FIRM            Unreviewed;       701 AA.
AC   R6LM74;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Putative penicillin-binding protein 2 {ECO:0000313|EMBL:CDB86960.1};
GN   ORFNames=BN515_00130 {ECO:0000313|EMBL:CDB86960.1};
OS   Firmicutes bacterium CAG:170.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263006 {ECO:0000313|EMBL:CDB86960.1, ECO:0000313|Proteomes:UP000018279};
RN   [1] {ECO:0000313|EMBL:CDB86960.1, ECO:0000313|Proteomes:UP000018279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:170 {ECO:0000313|Proteomes:UP000018279};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB86960.1}.
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DR   EMBL; CBEH010000113; CDB86960.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6LM74; -.
DR   Proteomes; UP000018279; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 2.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018279}.
FT   DOMAIN          53..294
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          346..672
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   701 AA;  77664 MW;  2F41CE953676B6F2 CRC64;
     MGRITRFRTI IFLCLVALLM GGYVLRLYKL QAVEPENGLV TADADSMQYM TTVEAARGNI
     LDRNGNILVS NRASYNLVII NFVLFNAKQP NERLLQLLEL CDDLGIRYAS HFPVTAEIPY
     SYNMDALDSS QQKYFRSFLD NRDYDLDISA QTLMKKLRAG YRIPSDWTQE QAYKVISVRY
     ELELRSIPGI GLENYTLASD VSAENLAAVM ELGIPGVIVE TGTVREFHTT SAAHLLGTIG
     QIYAEEADAY REKGYALNAL VGKSGVEQAF EEYLHGSSGT KYTTVSSDGE VLEEYFETVP
     QPGNNVELTI DISLQGVAEK ALEDVILNLR ENGVGRRQEG KDAEGGAVVV QDVKTGEILA
     SASYPTYNLA TFNEDYSELA QSEFGPFLNR VLQATYWPGS IYKMVTAIAA VDLGGYSEYY
     EITDKGIYEY YKEQNYEPRC YVWTSTSTTH GTINMREALQ ESCNYYFYEI GRLTYNKYMS
     ETGENPMDVV AKSLGLGEST GVELPEVTGT RANAETKAEL YSGQDAIWYG ADVIQAAIGQ
     SDNKFTPMQM VCYTSALANN GTRYKATFLS RVVSWDYQEL ILEHEPTVES RLDISDEAID
     CYKTGMELVA QKGTAAQYLS NYPIKVACKT GTAQWGNMHS GSDHASFVLY APADDPEIAI
     AVYVEKGAQG GNLANVCIPI LDAYFSDSSS HETALKENSA N
//