ID   R6M2U9_9CLOT            Unreviewed;       575 AA.
AC   R6M2U9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Adenylylsulfate reductase {ECO:0000313|EMBL:CDB90244.1};
GN   ORFNames=BN565_02399 {ECO:0000313|EMBL:CDB90244.1};
OS   Clostridium sp. CAG:253.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262785 {ECO:0000313|EMBL:CDB90244.1, ECO:0000313|Proteomes:UP000018071};
RN   [1] {ECO:0000313|EMBL:CDB90244.1, ECO:0000313|Proteomes:UP000018071}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:253 {ECO:0000313|Proteomes:UP000018071};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB90244.1}.
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DR   EMBL; CBEI010000132; CDB90244.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6M2U9; -.
DR   STRING; 1262785.BN565_02399; -.
DR   Proteomes; UP000018071; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR   Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR   InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR   InterPro; IPR030664; SdhA/FrdA/AprA.
DR   InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR   PANTHER; PTHR11632:SF82; FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT; 1.
DR   PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   Pfam; PF02910; Succ_DH_flav_C; 1.
DR   PIRSF; PIRSF000171; SDHA_APRA_LASPO; 1.
DR   PRINTS; PR00368; FADPNR.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR   SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          9..372
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
FT   DOMAIN          450..565
FT                   /note="Fumarate reductase/succinate dehydrogenase
FT                   flavoprotein-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02910"
SQ   SEQUENCE   575 AA;  63840 MW;  ACF179BD083FEAA2 CRC64;
     MDFRELTTDV LIVGGGTAGC YAAITLGQEK DIQVLIVEKA NIKRSGCLAA GVNAINAYIT
     EGHVPQDYVD YAKKDADGIV REDLLLSMSE RLNEVTAHME RLGLVILKDK DGKYVARGNR
     NIKINGENIK PILADAVKSL ENTTVINHVN ITDYIVENGV INGAYGFDVN DKTAYKINAK
     AVICATGGAA GLYRPNNPGF SRHKMWYPPF NTGAGYAMGI KAGAEMTTFE MRFIALRCKD
     TIAPTGTIAQ GVHAKQLNSD GEIYEDKYGL TTSQRLYGTV TENKEGRGPC YLKTDEISDE
     QQSDLYKAYL NMAPSQTLKW IESGRGPKNE NVEIEGTEPY IVGGHTASGY WIDNDRKTTI
     TGLYAAGDVA GGCPQKYVTG ALVEGEIAAQ SAVEYIRVIK DSENKKADYG NVSKNSDNAV
     NGLSSADKKA EYESYFSNPK GFIDTEQLEE TMQKIMDQYA GGISTNYEYN ESRLEIAKRK
     IDDIEKLSVN LHADDMDDLL RIYELKERLV VCKVLIEHLK ARKETRWHSF AENLDYPNKS
     DDYLKYVNSR YEDGKIKIIY RDLVTGGKVY EHSDK
//