ID   R6NMR9_9CLOT            Unreviewed;       820 AA.
AC   R6NMR9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Glycoside hydrolase family 38 {ECO:0000313|EMBL:CDC09704.1};
GN   ORFNames=BN649_01479 {ECO:0000313|EMBL:CDC09704.1};
OS   Clostridium sp. CAG:413.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262803 {ECO:0000313|EMBL:CDC09704.1, ECO:0000313|Proteomes:UP000018076};
RN   [1] {ECO:0000313|EMBL:CDC09704.1, ECO:0000313|Proteomes:UP000018076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:413 {ECO:0000313|Proteomes:UP000018076};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC09704.1}.
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DR   EMBL; CBES010000050; CDC09704.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6NMR9; -.
DR   STRING; 1262803.BN649_01479; -.
DR   Proteomes; UP000018076; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000313|EMBL:CDC09704.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018076}.
FT   DOMAIN          267..345
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   820 AA;  92224 MW;  26A6E7AB3471E5C5 CRC64;
     MNNSIHIIGN AHLDPIWLWR WQEGCGEVLQ TFRSAVDRLN EYDGFIFTCS SASYYKWVEE
     IDPELFVEIT KLVKKGRWVP VNGWWVQPDC NMPGTEGFAR QALYSQLYYY EKFGKICEVG
     YNVDSFGHNA MMPQLLTKSG MRCYVMMRPG MHENPDIPED LFWWDSADGS RVLTFRISDS
     YGASGTKSLD REVTNARKRA ENDGHGMMIF CGVGNHGGGP TKGDLDYLLK LKNEGYDELK
     FSSPDRYFEE MCADRLDLPV WSDELQHHAS GCYSATSMVK QLNRRAEFWL RSAEKWNTIA
     ALTTDLPAAT EKFAEAWRDV CFNQFHDILC GCSIMEAYDD VRDSMGGAMT VAAKEENKAL
     LKLSLNIDTW LDGVSDSVTC HERHHCRNLR FPRPIVVFNP LAHDVESPVR TYHPSKRVVD
     SDGNDTLFQN VRSSRSNDSH LDTEFIAKVP ALGYAVYWLW HEDSEFVEAP ELQSPVAADV
     LTIENEYLRV TFDDKNGGIS SLVSKEDGHE YVGGEFCVPA IFDNTKPDTW AHMIFRFHDE
     IAKPELASIE LVECGAARAV VRVKHVYNGS YLTQDFILAA GSKVIRVKCR ILWQEPLTIL
     KMPVTVAGSA PISTYEIPAG FIKRPCNGEE EPALTWGDVT AEGYGVSLIS DAKYSYDCPG
     GTLRLTMLRN CIFADHYSNR PAADFSYTDE GLQRFEYAIY PHKGAAEASE VQQEADKLNQ
     KLVAVPVGYH KGALPRMKSF ISVNKPNISL SALKFCEDGS GDVIIRLCET AGKPVKAAIV
     CDAANAGFYA DFGRQEVKTF RIDKDGFVKE TDFLEGVTEE
//