ID   R6NWL1_9CLOT            Unreviewed;       335 AA.
AC   R6NWL1;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=NAD-dependent epimerase/dehydratase {ECO:0000313|EMBL:CDC10651.1};
GN   ORFNames=BN649_01819 {ECO:0000313|EMBL:CDC10651.1};
OS   Clostridium sp. CAG:413.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262803 {ECO:0000313|EMBL:CDC10651.1, ECO:0000313|Proteomes:UP000018076};
RN   [1] {ECO:0000313|EMBL:CDC10651.1, ECO:0000313|Proteomes:UP000018076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:413 {ECO:0000313|Proteomes:UP000018076};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC10651.1}.
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DR   EMBL; CBES010000065; CDC10651.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6NWL1; -.
DR   STRING; 1262803.BN649_01819; -.
DR   Proteomes; UP000018076; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48079; PROTEIN YEEZ; 1.
DR   PANTHER; PTHR48079:SF6; PROTEIN YEEZ; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018076}.
FT   DOMAIN          7..221
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   335 AA;  37127 MW;  2F4753C7EE9D4CE7 CRC64;
     MEKKLNVVTG AKGYVGYALV KELADRGERI RLSLHRDSHD FDEFNCEKVI GDVCSLDHLM
     QAFEGADTVY HVAGLVDITG KKDDLVWKVN YDGTKAVVEA CKKCGVKNLV YVSSVDAIHV
     TDDMTVVREP DHFDPDLVNG AYGKSKAAAS QYVMDSSDEN LKTCVVHPSC CIGPYDVKGT
     ASVCAMIRLY IKGLFPVTLD FGAYNFVDVR DVAKGMIGAA EKGRGGQNYL LCGDKLTVRE
     FIATLAKICG RKPPKVALSK KTIIRLLPVI VKVFDMLKLP PVLNEMSIEI LCQNCNFTYE
     KAAKEFGYKP MSAEDSLRDT IKWIKKFDKE KANKK
//