ID R6PAK5_9BIFI Unreviewed; 1377 AA.
AC R6PAK5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN571_01566 {ECO:0000313|EMBL:CDC15556.1};
OS Bifidobacterium pseudocatenulatum CAG:263.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1263060 {ECO:0000313|EMBL:CDC15556.1, ECO:0000313|Proteomes:UP000018036};
RN [1] {ECO:0000313|EMBL:CDC15556.1, ECO:0000313|Proteomes:UP000018036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:263 {ECO:0000313|Proteomes:UP000018036};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC15556.1}.
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DR EMBL; CBEV010000093; CDC15556.1; -; Genomic_DNA.
DR Proteomes; UP000018036; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 8..385
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 386..764
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1377 AA; 150665 MW; 680AA324C961B5C7 CRC64;
MSGTMKFTDS PEQAAVVQAP SYADVVVVAG AGSGKTYTMT RRIITLIEQG VSPEKILGLT
FTRKAASELL SRVSAAVTRD QRERGLKSAN MTFLKPEVST YDAFFQSIVR QYGLLVGFDQ
NTQPLSEAGA MQLIHTVLDR HMDDLMAFDG DLKSFNTIAG NVFSLSNAIS GAMIGGDCTS
FDEAVQRVRD WDEAFVEQIA KALDGETVPT EEPKSPKLPK RLKKDSDADY EKKLEKYREL
GHDMCVFNSA QLAFVAKQRD LLLDLVLDYH AEKRACNMAE FSDFTIAAFQ LVSRFPSIGA
AYRKRYSHVL LDEYQDTSTT QAALLSALFH VDDTHRSAVN AVGDPFQSIY AWRGASPGAF
RMLQHDFGMD ATSRPFALTV TRRNSRMVLE AANNLTKPLR LPARRLSSSL MREVDVPALV
NTDEAPEGTV GVLAFDTFGQ EVDAVVRFVK HAIALHTPSS RDLDNGMKDN RPHVAVLFRS
KGIMPQFAEA LERAGLTTLV VGRSALLERP AVQDVFALLR VVSDHTDSAA LMRLLATPRF
SISANDLQAL ADTAEQVNTM CRYRALVSAG IVQEQSNKEE KPENLGIYGV TPKSGPSDAE
IRAIVREYRD QVPNAVFLVD LMLRDDLAEL IDGRVSREGT KEVLRAADAI RQVQRMLGHP
LPEVVREAIV ALNLDIDMQL AEHMRGGQAD ATLAASRVAL AKSPIDALLK LVDTYMQEIA
SQGTPSLRAF ISWADSLRDA REEHAVAPDV PVDVVLMTVH QSKGLEWDAV AVVGMTDGGF
PTNKGSDLRV VVDEEHLNGF QDGVWTPPEY HETAKTWLTD PAAVPVPVRV DADILPRFPH
DALVGGNPLE ALEMLEDAEI IDDEVFGTLR NMSVDDMEGI DPDGLYLTQI EEYGRRLHAD
ERRLAYVALT RARHEALLTC SATNAESRDP RAVGDRKRVS KPSNFLVEVR DSMLNIVSRA
AEPSNLADIA EVEDVDSSEN GMTSLHSIDA PLPDGFFVGE HARDFEDAVV GDAWNAPLEP
SEGNQFLPWP CELSDETLQT LRLSALQVDS AMNNAGGQTD GRAGERAGGQ VGGPVGGEGA
GRCENTGASL LRCAQLLVAD SNLMPDMLGE ASQDAFDSAV RAKGERILAS GRQNVTSLQA
RAGMMDERGA RTYWRGLVRP IPNVASPAAQ LGTQFHAWAE RFIMADANDA GIGVGASGNG
GTRVAESRLA MLAELRRNNA AQSQDNQDDN GADNNGIFDW QQRLATSTWA RRKPAWAERQ
IVVNVPQLGT IVNGKLDAVF FGGLDGVDRS KQYTIVDWKT GKKPRKKEEI QKKLAQLDMY
RILLSAMEGV PLTAIDACLY YLSEPIEGDR QLNAVDKTEE EILAELSYGI PEQSDND
//
