ID   R6PAS4_9FIRM            Unreviewed;      1416 AA.
AC   R6PAS4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Putative CoA-substrate-specific enzyme activase {ECO:0000313|EMBL:CDC20575.1};
GN   ORFNames=BN582_00898 {ECO:0000313|EMBL:CDC20575.1};
OS   Eubacterium sp. CAG:274.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1262888 {ECO:0000313|EMBL:CDC20575.1, ECO:0000313|Proteomes:UP000017904};
RN   [1] {ECO:0000313|EMBL:CDC20575.1, ECO:0000313|Proteomes:UP000017904}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:274 {ECO:0000313|Proteomes:UP000017904};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC20575.1}.
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DR   EMBL; CBEX010000079; CDC20575.1; -; Genomic_DNA.
DR   STRING; 1262888.BN582_00898; -.
DR   Proteomes; UP000017904; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017904}.
FT   DOMAIN          7..216
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          321..574
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          671..887
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   1416 AA;  156879 MW;  88077EFA6FE01CC8 CRC64;
     MSFYKAGIDI GSTTIKFVVM DENNNICFKD YRRHLSNIQE TLLGLVKDAR EQLGEFKFSC
     VITGSGGLSI SNWIGMEFIQ EVVAVSTAIN HVAPRTDVAI EIGGEDAKII YFDGGSIEQR
     MNGVCAGGTG SFIDQMASLL QTDAEGLNEY AKTYSAIYPI AARCGVFAKS DIQPLINEGA
     AKSDLAVSIF QAIVNQTISG LACGKPIRGN VAFLGGPLHF LTELKARFID VLGLEGDAVV
     EVEDSHLFAA MGSALSSKDD KIFSADEMIK ELTNGKHITM EINRLDPLFK DEQDYNKFKE
     RHDKAKVIKG DLESYKGDVF LGIDAGSTTS KLALISDKGE LLYSFYAGNE GSPLKMVMTA
     LKHIYSILPE GVTIKKSCVT GYGEALIKEA LMVDLGEIET VAHYKAAAFF EPDVDFILDI
     GGQDMKCIRI KNGVIDSVLL NEACSAGCGS FIETFAKSLK LSVQDFAKVA LFAKGPIDLG
     SRCTVFMNSR VKQAQKEGAE VADISAGLAY SVIKNALQKV IKVTDPTDLG KHIVVQGGTF
     YNEAVLRAFE KISTREAIRP DISGIMGAFG AAVISRDKYV AGEESTILNA EDLENLEIQS
     SLTRCKGCSN NCLLTINKFS GGRRFISGNR CERGLGKEKS DSCVPNLFQY KYDRLFDYEP
     IPENEAKRGV VGIPRVLNMY EDFPLWFTFF TKLGYSVKLS PKSSRKVYEM GIESIPSESA
     CYPAKIVHGH IMSLINDGVK FIFYPCVAYE HKEISGADNH YNCPIVTSYP ENIKNNVEEI
     RDYNIDFRNP FIALSSEEIF ADRMAEIFGD IPKNEVKEAA KAAWREEQRF REDMRKKGEE
     TVKYIKENNM TGIVVAGRPY HIDPEINHGL PELITGYGVA VLTEDSVAHL GNVERPLNVR
     DQWAYHSRLY AAASFVREQE DIELIQLNSF GCGLDAVTTD EVHDILDAYG KIYTVLKIDE
     VSNLGAARIR IRSLFAALEE RRNKKFKPKK LVEKESRVVF TKEMKKTHTL LMPQMSPIHF
     DIAQEAFRAS GYNVEVMPAI DKDCIDIGLK YVNNDACYPA LIVVGQILRA LQSGNYDLDK
     VSVLISQTGG GCRATNYIGF IRRALKNAGL EHIPVVSVSA SGLEKNPGFK ITYKFAMALL
     QSVLYGDLFM RVLYKTRPYE KVKGSANALY HKWNEVCKKA VRSPKKNEFN KIVRGIVKDF
     DELPLDETIV KPKVGVVGEI LVKFHPTANN DVVTLLEKEG AEAVVPDLIN FFTYSLYNNK
     YKEEYLGAKH SITVLTNWAI KFIEGYRRVM GDALKASKRF DPPTDIKELG AMAEDIVSLG
     NQTGEGWFLT GELVELIHSG VTNNICAQPF ACLPNHVTGK GVIKELKRRN KNSNIVAIDY
     DPGASEVNQL NRIKLMLSTA YKNLEKSQKE AAASNK
//