ID   R6PWB2_9FIRM            Unreviewed;       461 AA.
AC   R6PWB2;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Putative oxidoreductase {ECO:0000313|EMBL:CDC14012.1};
GN   ORFNames=BN662_01127 {ECO:0000313|EMBL:CDC14012.1};
OS   Roseburia sp. CAG:45.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=1262947 {ECO:0000313|EMBL:CDC14012.1, ECO:0000313|Proteomes:UP000018173};
RN   [1] {ECO:0000313|EMBL:CDC14012.1, ECO:0000313|Proteomes:UP000018173}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:45 {ECO:0000313|Proteomes:UP000018173};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC14012.1}.
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DR   EMBL; CBET010000162; CDC14012.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6PWB2; -.
DR   Proteomes; UP000018173; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   InterPro; IPR006004; SudA-like.
DR   NCBIfam; TIGR01316; gltA; 1.
DR   PANTHER; PTHR43100; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   PANTHER; PTHR43100:SF1; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018173}.
FT   DOMAIN          17..127
FT                   /note="Dihydroprymidine dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF14691"
FT   DOMAIN          140..447
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
SQ   SEQUENCE   461 AA;  49437 MW;  E802688BB304B451 CRC64;
     MEGLTRVPVR EQEPEVRAAN FEEVCLGYNE EEAVAEAKRC LNCKNAQCMK GCPVSINIPA
     FIAQVKEGNF EEAYHIISES SALPAVCGRV CPQESQCEGK CIRGIKGEPV AIGKLERFVA
     DWAREHGIKP KKAEKLNGHK VAVIGSGPAG LTCAGDLAKL GYDVTIFEAL HEAGGVLIYG
     IPEFRLPKSK VVAAEVENVK ALGVKIETNV VIGKAVTIDE LMEKEGFEAV FIGSGAGLPR
     FMGIPGEQAM GVFSANEFLT RNNLMKAFRD DYDTPIKAGK KVVVVGGGNV AMDAARTAKR
     LGAEVHIVYR RGEEELPARK EEVHHAKEEG IIFDLLQNPT EILVDEDGWV KGCRVIKMEL
     GEPDASGRRS PVEIPGSEYE IEADTVIMSL GTSPNPLISS TTKGLDINRR KCIIAEEETG
     ATSKDGVYAG GDAVTGAATV ILAMGAGKTA AKGIDEFLRN K
//