ID   R6QH91_9FIRM            Unreviewed;       672 AA.
AC   R6QH91;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Penicillin-binding protein transpeptidase domain protein {ECO:0000313|EMBL:CDC32364.1};
GN   ORFNames=BN563_00009 {ECO:0000313|EMBL:CDC32364.1};
OS   Eubacterium sp. CAG:251.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1262886 {ECO:0000313|EMBL:CDC32364.1, ECO:0000313|Proteomes:UP000018414};
RN   [1] {ECO:0000313|EMBL:CDC32364.1, ECO:0000313|Proteomes:UP000018414}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:251 {ECO:0000313|Proteomes:UP000018414};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC32364.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CBFD010000012; CDC32364.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6QH91; -.
DR   STRING; 1262886.BN563_00009; -.
DR   Proteomes; UP000018414; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018414}.
FT   DOMAIN          53..296
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          336..651
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   672 AA;  73854 MW;  035BC78D57EED8C1 CRC64;
     MKSKYKSGRS VFALIVVCLV IFSFAADLFN IQVKNNEYYA AQNNTESKYV VELEAARGEI
     VDRNGNSLVT NRQGNSIILN AAFFPSQKDN KRRNEIIYNL IKLFEKNKEE YAQNLPLKIT
     KSGKVKFSGK KEDIATMKSA DMLNLQPYAT AQNCFDAMIE KYEIEGYDAQ TALKIGNIRY
     ELTRLLFSYE NPVTIADDVS DETVAMIKED RETYLGADVR IVAYREYVDS TIAPHILGTV
     RKINAEEYNE RKDDGYKITD QIGESGIEQA CESELRGTPG ELTITITKDG EITQEVTKKP
     IQGNTVVLTI DRDLQVLAQN RLQGVCNKVN AASSAGAVVV EDVNSGELLA AASYPTYDLN
     DYYDKYDELI SNPRNPLWSR FAMGTYAPGS TFKPVVASAS LEEGAISADT IFNCGGTMEY
     RKQKFKCLHG NAHGGENVKT ALRDSCNIFF YNCAMRLGIS KIDEYATAFG LGEKTGVEIA
     ESSGILASPE NRENNGGIWN AGDTLQTAIG QSDNLFTPLQ LANYCSTVAN GGTRYELHFV
     KSIISSASGN VNEKTKSVAE SVGLSQSTIN TVHQGMRLVA TNGGPYLVFS NMKTKVACKT
     GTSEVKVNGA KRNNGFLITF APYNHPEIAV SSVVELAGSG SETAEMTKDI INYWYQNNTD
     AKENQKVGTL LP
//