ID R6R4Q0_9FIRM Unreviewed; 462 AA.
AC R6R4Q0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:CDC42920.1};
GN ORFNames=BN652_02748 {ECO:0000313|EMBL:CDC42920.1};
OS Firmicutes bacterium CAG:424.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1263022 {ECO:0000313|EMBL:CDC42920.1, ECO:0000313|Proteomes:UP000018167};
RN [1] {ECO:0000313|EMBL:CDC42920.1, ECO:0000313|Proteomes:UP000018167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:424 {ECO:0000313|Proteomes:UP000018167};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC42920.1}.
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DR EMBL; CBFI010000012; CDC42920.1; -; Genomic_DNA.
DR AlphaFoldDB; R6R4Q0; -.
DR UniPathway; UPA00782; -.
DR Proteomes; UP000018167; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR43787:SF3; FEMO COFACTOR BIOSYNTHESIS PROTEIN NIFB; 1.
DR PANTHER; PTHR43787; FEMO COFACTOR BIOSYNTHESIS PROTEIN NIFB-RELATED; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018167};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 126..355
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 462 AA; 53561 MW; E852E512BE42756A CRC64;
MKMEMVTATA NPTQIQSRYN CSDSDFLIKQ KIIVENLYLI FRKVPMYYLV PYISIKNENN
IIYIESSINE NYIKITDSEL QSEFYKLKEN GCKTIDTPLL NCLHEQKFLL NKCELESNLA
SIRHLMDERL ILTLMPTESC NFRCPYCYES HNTITMNQEI IEKIKNYIQL HVSEFSVISI
IWFGGEPTLC ADMIFNFSEF VKALQSRQNF QYNASMTTNG YLLTKELFIK FYELGITSYQ
ITIDGWNHDQ TRPLASGKGT LDVILKNLQD ISSLDQAQYS FHITIRHNIL KDDTDFTWYD
YLYQYFGKDG RFSVLIRPIG DWGGETVKKL DLLSLPERDH LVLQHINYLK EIGMDCSNGG
KGIFSKICYA GFPHSMVFRA NGKIEKCTVA LNHPKNLIGF VDTDKGVCID ENANQLWWQP
NLLSKCYSCP KVLSCFNMQC PKNQLIDGYP PSICTDEYDK IY
//
