ID R6RHR4_9FIRM Unreviewed; 602 AA.
AC R6RHR4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Beta-xylosidase {ECO:0000313|EMBL:CDC47335.1};
GN ORFNames=BN788_02219 {ECO:0000313|EMBL:CDC47335.1};
OS [Eubacterium] siraeum CAG:80.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Oscillospiraceae incertae sedis.
OX NCBI_TaxID=1263080 {ECO:0000313|EMBL:CDC47335.1, ECO:0000313|Proteomes:UP000018142};
RN [1] {ECO:0000313|EMBL:CDC47335.1, ECO:0000313|Proteomes:UP000018142}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:80 {ECO:0000313|Proteomes:UP000018142};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC47335.1}.
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DR EMBL; CBFJ010000142; CDC47335.1; -; Genomic_DNA.
DR AlphaFoldDB; R6RHR4; -.
DR Proteomes; UP000018142; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd09001; GH43_FsAxh1-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR041542; GH43_C2.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF13; HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED; 1.
DR Pfam; PF17851; GH43_C2; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000018142};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..602
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038528523"
FT DOMAIN 404..597
FT /note="Beta-xylosidase C-terminal Concanavalin A-like"
FT /evidence="ECO:0000259|Pfam:PF17851"
FT REGION 28..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 92
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 256
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 203
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 602 AA; 68029 MW; 82E9DE501B174281 CRC64;
MKRLVRFAAA LMAVLTLTAC TAEVGTSSVT STPMSTTTST STSNPLPSVT TEPGKEEDPK
VLDKDIIKST ITSTDDGKGN YTNPVIFADV PDIDIIRVDD AFYMVSTTMH LSPGCPVMKS
YDLVNWEIVN YVFDTLEDSD KLALRNGENN YGKGQWATTL RYNNGVYYAG FTSFSTGKTY
IYHTDDIENG KWDRFVYDEC FHDMSLLFDD DGKVYLIYGG GEIYCVELEK DLSAVKPGTK
RKLINNAGLV KGCLAEGSHV YKLNGYYYIF IITWPPNSKR TQLCYRSEAL DGEWERKVII
RDNMGFRNDG VAQGGIVDDK DGNWYCFVFQ DHGAVGRTPV VSTMTWEDGW PVVGVKGKVP
TTAKIPIAGH EKKGIVTSDE FINSHIVRSY HSFADTPEEA GESDYNGSNL GLEWQWNHNP
DNRLWSLTER EGYLRLRTVD VCGTVANARN TISQRTFGPE CGAYIKLDVS EMKEGDVAGF
AAFAEKYGYV AVKIEDGKKY IVTVWYDDND DVEKEFETER VEITENEVYL RVDCDFKNAT
DKAYFYYSLD GENWTKIGDT LQMNYYGLHF MGYRYAIFNF PTKQTGGYVD VDYFRVENKL
LK
//
