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Database: UniProt
Entry: R6T174_9FIRM
LinkDB: R6T174_9FIRM
Original site: R6T174_9FIRM 
ID   R6T174_9FIRM            Unreviewed;       796 AA.
AC   R6T174;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=GTP diphosphokinase {ECO:0000256|ARBA:ARBA00013251};
DE            EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
GN   ORFNames=BN714_00007 {ECO:0000313|EMBL:CDC67213.1};
OS   Ruminococcus sp. CAG:57.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Ruminococcus.
OX   NCBI_TaxID=1262962 {ECO:0000313|EMBL:CDC67213.1, ECO:0000313|Proteomes:UP000018131};
RN   [1] {ECO:0000313|EMBL:CDC67213.1, ECO:0000313|Proteomes:UP000018131}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:57 {ECO:0000313|Proteomes:UP000018131};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate;
CC         Xref=Rhea:RHEA:22088, ChEBI:CHEBI:30616, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:142410, ChEBI:CHEBI:456215; EC=2.7.6.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001157};
CC   -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC       1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC67213.1}.
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DR   EMBL; CBFS010000207; CDC67213.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6T174; -.
DR   UniPathway; UPA00908; UER00884.
DR   Proteomes; UP000018131; Unassembled WGS sequence.
DR   GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015970; P:guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04876; ACT_RelA-SpoT; 1.
DR   CDD; cd00077; HDc; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF19296; RelA_AH_RIS; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018131}.
FT   DOMAIN          115..214
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   DOMAIN          454..517
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
FT   DOMAIN          722..796
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
FT   REGION          19..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   796 AA;  91059 MW;  F9246E7B42A86EAD CRC64;
     MSDKENILLD PAEMDKIENI PEIKTVSEED LPAESEVKEQ FEEKPAPTAS PDYTDAVPEA
     SKPEHIGERS VCSIDALIQK ILDGERQYDL SKIVSAYELA EKYHHNQKRE SGEPYITHPL
     SVAYILLELG MDTDTICAAL LHDVVEDTPC TLEELQKNFG SDVAMLVNGV TKLKKVETFT
     KDEQKAENIR KILLAMSEDI RVIIIKLADR LHNMRTLNYC KDSKRRTIAH ETMNIYAPIA
     HRLGIRSIKD EFEDLAFYYL DPYAYAEIDE QMQLRKGSRE QLVENIKHKI HDRLEKDFDP
     VPLIEGRVKS NYGIYKKVYR DGKEIDQIYD RYAVRIIVNT VTECYNVLGI IHDMFRPIPN
     RFKDYISTPK ANMYQSLHTT VIGREGIPFE VQIRTWEMHR TAEYGIAAHW KYKEGVRGSS
     KDDQRLAWIR QIIESQQESN DVEEIVRAIK NDLAPEDVFA FTPKGDMITL PVGSTVIDFA
     YAIHTQVGHK MCGAKVDKKM VSYDYQIKTG EIIEILTTNV EGHGPSRSWL NICKTNEAKS
     KIRSWFKKER REENIFEGRN ALEREFRRNN IRVPEEELED FLKMDMHRHS CDTLDDFFAA
     IGYGGVQLSK VMQRLKSEYN KKYGEKAQPD TSDLENKIKT SKNSTGVIVD GIDNCAIKFA
     QCCNPLPGDE IVGFITRGHG ISVHKKDCVN YLSQKDDPEN AARWINVKWE SSEKHTGYFK
     CTLDIVAVDR IGLLADVSSA LAMINIFIYE STSRELKNGN AMLSVTVSIA GMEQLNNVIN
     KLQKIKNVIS VERSGK
//
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