ID   R6V2N9_9FIRM            Unreviewed;       606 AA.
AC   R6V2N9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Histidine kinase-DNA gyrase B-and HSP90-like ATPase./Histidine kinase./HAMP domain {ECO:0000313|EMBL:CDC92438.1};
GN   ORFNames=BN635_00787 {ECO:0000313|EMBL:CDC92438.1};
OS   Roseburia sp. CAG:380.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=1262946 {ECO:0000313|EMBL:CDC92438.1, ECO:0000313|Proteomes:UP000017909};
RN   [1] {ECO:0000313|EMBL:CDC92438.1, ECO:0000313|Proteomes:UP000017909}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:380 {ECO:0000313|Proteomes:UP000017909};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC92438.1}.
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DR   EMBL; CBGD010000026; CDC92438.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6V2N9; -.
DR   STRING; 1262946.BN635_00787; -.
DR   Proteomes; UP000017909; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR   PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR   PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF06580; His_kinase; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CDC92438.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017909};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        310..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          325..377
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
SQ   SEQUENCE   606 AA;  71359 MW;  715D5D3BAF8EEC9D CRC64;
     MNELNYKKRF HLFKDMKFLH RMILIYLIGG IIPLLVMSIY TNMQTRKMMI KLTEETQAQE
     LSVFSSSIRE SMTVLDNVAR LLCSNDEILK LTTRKYKNKT QFYSDYRKAN TVMEDYINFY
     EQDISSINLF LDNPTIDTYD LNRINNLSYF KQSVRTQTWY KETVDCVDEG YWYFGETSGD
     NEKDQTMQIS RAVRDDDDDV VGIVVIQIQY DKVTLNEQRQ DTAILYDDYY WISGNCSSLD
     YPFLKEEIQK INKSRVTKQI SYGVEEYLIS YERLQMDGSD DYYSVVSVQN YQDIMAEVNQ
     ISMQAFIPEI IGMIVSALLI FAFAASYSNR MFQLRVQMHR VAQGEYDEVE RIEGNDEIGE
     LYTELEQMMQ DIRLLMSNVV DEQVQKEKLH TKQKEVEFKM LASQINPHFL YNTLETIRMK
     AVVNHQPEIV ELVKMLAKTM RYNIQVTDRL VTLKEELQMV EYYLKIQEYR FGDRITSELT
     IDPDVDMKAR ILPLTLQPFV ENAFVHGLEE KACDARLVIH VYKKKDDIFI EIRDNGKGMD
     YYELGHLRKI MKDERGDDNH IGVRNVNQRI RLLFGGEYGV EVDSEKNVGT KVVIHIPYQT
     EIDQNV
//