ID   R6VD25_9FIRM            Unreviewed;       475 AA.
AC   R6VD25;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=Penicillin-binding protein transpeptidase {ECO:0000313|EMBL:CDC92244.1};
GN   ORFNames=BN546_01738 {ECO:0000313|EMBL:CDC92244.1};
OS   Firmicutes bacterium CAG:227.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263010 {ECO:0000313|EMBL:CDC92244.1, ECO:0000313|Proteomes:UP000018294};
RN   [1] {ECO:0000313|EMBL:CDC92244.1, ECO:0000313|Proteomes:UP000018294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:227 {ECO:0000313|Proteomes:UP000018294};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC92244.1}.
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DR   EMBL; CBGC010000122; CDC92244.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6VD25; -.
DR   STRING; 1263010.BN546_01738; -.
DR   Proteomes; UP000018294; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018294};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          176..467
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   475 AA;  52094 MW;  96A278B673F77433 CRC64;
     MFRKKEKLQS YINQVWRLFK VALVMMLVLA VVLGKRYLEA DAKTTMSEQE LDSSLLSLSE
     VYLPGTIYDK KDNVLMFGSE PGKLSWMSDK KSNSLERLIG GTDYIKAVET GNVRMTILGM
     APELLGESDS RMDEKSLFHP NQRRIGGNVK LTIDADLQNF IEDLLIENGY MDSSVMVSNF
     QTGEVEAAVC LGGDSSETVF SRKFHPASTM KLAIAASALE YDAKLANFSY TCKGNNTFTL
     DAEGKETVSV HCSGGNVHGT LTTMESAMAQ SCNGYFIALA QQVPEEILRK NLKKFGFDDV
     MHFDSFKFDD NTFMGESENA YDLVYGCIGQ GQASVTTIGL NMYTNAILNK GVLAEPHFIL
     KSSDKRGEAM KTKTQAVTRQ MCTEEVADSI KNMMVKVIKE GTGRDFAVDG VEMAFKTGTG
     EEGDGKTQTL LVTGGILNEN KPYSITVCLN HINGGSSVNA GLIAKEIVNR LVAEE
//