ID R6WH87_9FIRM Unreviewed; 270 AA.
AC R6WH87;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Global transcriptional regulator CodY {ECO:0000256|ARBA:ARBA00034538};
GN ORFNames=BN635_01293 {ECO:0000313|EMBL:CDC93542.1};
OS Roseburia sp. CAG:380.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1262946 {ECO:0000313|EMBL:CDC93542.1, ECO:0000313|Proteomes:UP000017909};
RN [1] {ECO:0000313|EMBL:CDC93542.1, ECO:0000313|Proteomes:UP000017909}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:380 {ECO:0000313|Proteomes:UP000017909};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC93542.1}.
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DR EMBL; CBGD010000087; CDC93542.1; -; Genomic_DNA.
DR AlphaFoldDB; R6WH87; -.
DR STRING; 1262946.BN635_01293; -.
DR Proteomes; UP000017909; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR013198; GTP_trans_reg_CodY_C.
DR InterPro; IPR010312; Transc_reg_CodY_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40062:SF1; GLOBAL TRANSCRIPTIONAL REGULATOR CODY; 1.
DR PANTHER; PTHR40062; GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000017909};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 12..184
FT /note="Global transcriptional regulator CodY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06018"
FT DOMAIN 208..259
FT /note="Global transcriptional regulator CodY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08222"
SQ SEQUENCE 270 AA; 30728 MW; 498566224769DAB8 CRC64;
MEKEQGFTMS LELLDKTRKI YRLLNRQESD KVDFNDFCRM LSQEMEVNVL LLSRKGKVLG
MRLRKEIPVI PQMSGVAYGS YFERQIHERM LNILSTKENV NLMTLGFSFE GVQDYQAMVA
PVNMAGKRLG TLFVYRQAGA FSIDDIILME YGMTVIGLAM QRAESEELSE EQHKENDVRA
AIRTLSRLEA KAMLYVLDEL EENDSDMLVT SRLADQVGIT RSVIVNGLRK CESAGIISTK
SGGMKGTSIH LLNERFTPEM IRSCMEEQNL
//
