ID R6YK90_9BACT Unreviewed; 854 AA.
AC R6YK90;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN655_01456 {ECO:0000313|EMBL:CDD18822.1};
OS Alistipes sp. CAG:435.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC Alistipes.
OX NCBI_TaxID=1262695 {ECO:0000313|EMBL:CDD18822.1, ECO:0000313|Proteomes:UP000017965};
RN [1] {ECO:0000313|EMBL:CDD18822.1, ECO:0000313|Proteomes:UP000017965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:435 {ECO:0000313|Proteomes:UP000017965};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD18822.1}.
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DR EMBL; CBGN010000081; CDD18822.1; -; Genomic_DNA.
DR AlphaFoldDB; R6YK90; -.
DR STRING; 1262695.BN655_01456; -.
DR Proteomes; UP000017965; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 10..295
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 296..596
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 723..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 31..38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 854 AA; 95093 MW; BCD2E6799607595D CRC64;
MEKYESAIFE GLNAEQKKAV GSVDGPVLIV AGAGSGKTRV LTSRIAYILE RGCDPARIMA
LTFTKKAATE MKERIAVMVG DRKARRLFMG TFHSIFIRFL REYAALLGYP STFTIYDTSD
SVSGIKACIK ELGLDEKVYK PKDVLSRISM AKNNLITATA YRNNQQAIIN DTHARKPRIC
DIYSRYAEKC KNSGVMDFDD ILLNMNILLR DFPEAKDAIA SRFDYYLVDE YQDTNFAQYL
ILKKLTKKHR NLCVVGDDSQ SIYAFRGAKI ENILNFKKDY PECRIFRLER NYRSTANIVN
AANSLIAKNE NRIPKTCVAV GEEGEKIRLL KSWSEQDEAI TIASEIVERM QSDHAKYQDF
AILYRTNSQS RALEEALRKR NLPYMIYSGN SFFDRAEVKD MMAYLKLVVN VNDDESFKRI
VNTPARGIGD TSLNALAAMA FDLKCSLFKA ACSEKFADYG LKPAAVAKIR SFCEMINGFA
AKEATTNADE LALGISNACG LYAFFKNDPS IEAQSRASNV EELINSVTHF IEEQRESYFR
DLLAEGEAED DSEVEYPVFT LGAFLENISL LSNVDVEDEE DTNNKIALMT VHSAKGLEFP
YVFVAGLEEN IFPSGGMLIS PAEIEEERRL FYVAITRAKK AVCLSFANTR MRNGKHESNS
PSRFIKEIDT KYIANPLRND NFSDDDSLDF EDFGGFGSRG FGSGNGSGSG SGRFPGGSYG
SGRSSGAYGN GSSGRFGGEN RPANKYGMGG GNSYGSSGSV RYERKPASAP RLSDTASKIE
ALRNRPLPPK ISDTDFVPAP MTDFKVGQRI EHNRFGQGKI LEITGDAPDL KAKITFDHYG
EKLLLLKYAK MRVL
//
