ID R6YUP1_9CLOT Unreviewed; 559 AA.
AC R6YUP1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Cell wall-associated hydrolases (Invasion-associated proteins) {ECO:0000313|EMBL:CDD39718.1};
GN ORFNames=BN593_01282 {ECO:0000313|EMBL:CDD39718.1};
OS Clostridium sp. CAG:299.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262792 {ECO:0000313|EMBL:CDD39718.1, ECO:0000313|Proteomes:UP000017929};
RN [1] {ECO:0000313|EMBL:CDD39718.1, ECO:0000313|Proteomes:UP000017929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:299 {ECO:0000313|Proteomes:UP000017929};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C40 family.
CC {ECO:0000256|ARBA:ARBA00007074}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD39718.1}.
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DR EMBL; CBGZ010000091; CDD39718.1; -; Genomic_DNA.
DR AlphaFoldDB; R6YUP1; -.
DR STRING; 1262792.BN593_01282; -.
DR Proteomes; UP000017929; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR003646; SH3-like_bac-type.
DR PANTHER; PTHR34408; FAMILY PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR34408:SF1; GLYCOSYL HYDROLASE FAMILY 19 DOMAIN-CONTAINING PROTEIN HI_1415; 1.
DR Pfam; PF00877; NLPC_P60; 1.
DR Pfam; PF08239; SH3_3; 4.
DR SMART; SM00287; SH3b; 4.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS51935; NLPC_P60; 1.
DR PROSITE; PS51781; SH3B; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CDD39718.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017929};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..170
FT /note="SH3b"
FT /evidence="ECO:0000259|PROSITE:PS51781"
FT DOMAIN 181..244
FT /note="SH3b"
FT /evidence="ECO:0000259|PROSITE:PS51781"
FT DOMAIN 257..323
FT /note="SH3b"
FT /evidence="ECO:0000259|PROSITE:PS51781"
FT DOMAIN 334..396
FT /note="SH3b"
FT /evidence="ECO:0000259|PROSITE:PS51781"
FT DOMAIN 438..559
FT /note="NlpC/P60"
FT /evidence="ECO:0000259|PROSITE:PS51935"
FT REGION 407..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 60507 MW; DBC9528A4328CD02 CRC64;
MGINKPDDYA ARLLKARKRR NGKDPLKYFL IAAGCVIVIL VIVLAGKLAK GGRIDLGAGR
TGKGPEIEGV FESEGSTEAA QGDLMDEDEE LRKIDEQKAA VVESYENLGI VQVTGYLNMR
ESPDQNADII GKMLNGSACE ILDDSQEGWY QVTSGGLTGY ISSEYVLTGD EAKTAAFDLV
DQMAVITADK LNVRSEPNQD AQVLEQVLRN ERYTIEEEEG DWIKIPDGYI SSEYVQERYA
LNEARKLDLR TMVLNMYDNI GISNINNYLN IRKEPKEDGK IIGKMISKSA GEILETTEDG
KWYKIKSGPV TGYVSSEYIL TGQAAKDEAL QEAKLMAIVS TDRLNARTEP NTEAPIWTQI
SNSERYNVLS QQNGWVEIEL DTTSAYVATD YVDVRYALNE AIEFTPVEET SDTGSSGGKG
GSGGKGSSGS KGSSGSGSSK RSQIASYATQ FLGNPYVWGG TSLTNGADCS GFTMAVMSHF
GVSLPHHSGS QANAGRAVSS SEMRPGDLVF YTNSGGTINH VALYIGNGQV VHASNPSSGI
KISRWNYRTP AKIVNVLGD
//
