ID R7BF60_9FIRM Unreviewed; 965 AA.
AC R7BF60;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=DNA translocase FtsK {ECO:0000313|EMBL:CDD64409.1};
GN ORFNames=BN803_01656 {ECO:0000313|EMBL:CDD64409.1};
OS Firmicutes bacterium CAG:882.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1262991 {ECO:0000313|EMBL:CDD64409.1, ECO:0000313|Proteomes:UP000017928};
RN [1] {ECO:0000313|EMBL:CDD64409.1, ECO:0000313|Proteomes:UP000017928}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:882 {ECO:0000313|Proteomes:UP000017928};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homohexamer. Forms a ring that surrounds DNA.
CC {ECO:0000256|ARBA:ARBA00025923}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD64409.1}.
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DR EMBL; CBHL010000048; CDD64409.1; -; Genomic_DNA.
DR AlphaFoldDB; R7BF60; -.
DR Proteomes; UP000017928; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000017928};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 617..814
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 634..641
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 965 AA; 105957 MW; 06C80E4C7B126959 CRC64;
MAASRQTSPE KKRTTQSHRT TAKSAATGSK RTASSGSRAS SGSRSRKKKK KISSAAFNEA
ALFIALAVAL ILFISNFGLA GKFGTFFEAL QFGTFGVLAY IFPLELVLGT YLMMRKGKKS
GVARVKFITA FIGSFFVCAF IEMINGAYKS MEKLSGYYNF AVPVKKGGGI IGGSICRFLT
PAVGKVGAYI IIVVFIIIAI LIISERSILK GLSSGSRKVF KTAKDDICEY KEESEKKRVQ
REEAREQEVT RRRRFNQKVS GVDFSIEIPR ERRDVDTADR LPQAENMRRR NSGIAGAEVE
EVFQNDRYSE NIIDISPENA VSGSVISLKK RKNAVTAKPV TPDVKENMNE VSEAGFKPDV
SEITEYKPQD DYTGYEASEE KNEQTYSSYG EHLQELPEDD GMEQWSRQAE VDAAGRAVLE
NIKRQQPAQP EKSTAAEVRK SVEPQASKNK EPERTMEQVD AEIDEELRQS EELNEEIVEE
EYKFPPVELL HRGRSSNSAS DKELHDTAMK LQQTLSNFGV RVTVSDVSCG PAVTRYEIQP
EQGVKVSRIV SLADDIKLNL AAADIRIEAP IPGKAAVGIE VPNKETSGVT LRELIESKPF
EESKSPIAFG VGKDIAGQVV VADIAKMPHV LIAGATGSGK SVCINTIIMS ILFRAKPSEV
KLIMIDPKVV ELSVYNGIPH LMIPVVTDSK KAAGALNWAV AEMDDRYKKF AQAGVRDLKG
YNAKVEQLKD IEAENKPARM PQLVIIIDEL ADLMMIAKNE VEDAIVRLAQ LARAAGIHLV
IATQRPSVDV ITGLIKANVP SRIAFAVSSG VDSRTILDMV GAEKLLGKGD MLFSPAGYPK
PARIQGAFVS DDEVSAVVEF LKANCGETGG YHNDVTEKIN NPAFAESQAF GNDYDDYFAE
AGRYLIEKGK GSVSILQRVY RIGFNRAARI MDQLEEAGVM GPEEGTKPRK VLMSMEEFEE
LLAKL
//
