ID R7F6V4_9CLOT Unreviewed; 573 AA.
AC R7F6V4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=BN623_00259 {ECO:0000313|EMBL:CDE10585.1};
OS Clostridium sp. CAG:354.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262799 {ECO:0000313|EMBL:CDE10585.1, ECO:0000313|Proteomes:UP000018313};
RN [1] {ECO:0000313|EMBL:CDE10585.1, ECO:0000313|Proteomes:UP000018313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:354 {ECO:0000313|Proteomes:UP000018313};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE10585.1}.
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DR EMBL; CBIG010000036; CDE10585.1; -; Genomic_DNA.
DR AlphaFoldDB; R7F6V4; -.
DR STRING; 1262799.BN623_00259; -.
DR Proteomes; UP000018313; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000018313};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 465..551
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
SQ SEQUENCE 573 AA; 66563 MW; CDA138D73CC46571 CRC64;
MAFDGITTKS ISYELQYSIL GGKINKIFEP NKNEVLLSIY ANGKNYALNI CIDSNLYRIH
LTTNAKPNPL NAPNFCMLLR KHLIGYKIKA ISSNDNLERI IKIELEGYNE LNDLTTKYLM
VELMGKHSNI ILLNDKFFII DSLRHLDTLS NSYRDILPAH EYTYPENVKN NFYTIKSAEE
FCNLVLTNNV TNLTNFLVGY FTGFSKPFIK NIIIKQNIRN TDFSKDDILK MYEYLSKILN
NLDSNHVSLT KYSNEKGKLD YVIDLETKTS NLDINFYIDD FYYNKEANNN YVSYRNNLLK
LISHILKKYS LRLESINNKL KECENKDLYK LYGELITANL YKFSKDYNSD KVELENYYDN
NTILTIPLDN TISIANNAKK YFKKYNKLKN ALEIVTLQKK ETEEELQYIE SIIYELEYAK
NIQEVNEIYN EISENPIFKD YIQSNNKTNT KKDANISTPR EYHIDGFTVL VGKNNKQNDY
LTTKLASPND IWFHTKDIHG SHVILKNPSE NISNDTLIKC AKLAAYYSKG RLSSNVPVDY
CFVKYVKKPN GSKPGMVIYT NNKTLNVTPY ISD
//