ID R7FKT2_9CLOT Unreviewed; 580 AA.
AC R7FKT2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=AMP-forming long-chain acyl-CoA synthetase {ECO:0000313|EMBL:CDE15118.1};
GN ORFNames=BN670_01395 {ECO:0000313|EMBL:CDE15118.1};
OS Clostridium sp. CAG:470.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262812 {ECO:0000313|EMBL:CDE15118.1, ECO:0000313|Proteomes:UP000018084};
RN [1] {ECO:0000313|EMBL:CDE15118.1, ECO:0000313|Proteomes:UP000018084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:470 {ECO:0000313|Proteomes:UP000018084};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE15118.1}.
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DR EMBL; CBII010000085; CDE15118.1; -; Genomic_DNA.
DR AlphaFoldDB; R7FKT2; -.
DR Proteomes; UP000018084; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272:SF83; ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J; 1.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
FT DOMAIN 29..427
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 580 AA; 65517 MW; 227AD459D65E8265 CRC64;
MKEKLKISEE LKQKYHKCEE VTNFKQILDR SAEIYKTRTA FKLKDKDGNI YNKTYEELKA
DVTVLGTSLI ENGLLNKRIA VIGKNSYKWV ISYLAASIVG VVVPIDKELH SDDVINFMNV
SESKCILGDS KNLKKINENI EKLENKETLF IDFDSKIQEG NSLSFAVQME NGKTLVEEGN
TEFDKITVNP DELKILLFTS GTTGNAKGVC LSQRNICSNI LSIYGIVKVK RSDLFFSILP
LHHTYECTIG FLLPLYSGAS ICYCDGLRYI TSNMLEYHPS VILCVPLLLE KMYQKIMKSI
QKTLPKKYTE NLKENENIID KLPFYIKGIV KRKVKNSLGG RLRVFIVGAA AVNPEIADTF
DKLGLNSLQG YGLTECAPLV AGNTDFFKRN DSAGLPIPNV EYKIDNPDRD GVGEIIVKGP
NVMLGYYNMP EETEKVLKDG WFHTGDLGKI DENGFLYITG RCKSVIVTKN GKNIYPEEIE
AYLNDSPLIS ESLVMGIQKE NDDETYVNAQ IFPNMDAIKE YLKGTVPTKE EVKKIMADVV
SGVNSKIPNY KHIKNFAVRD KEFEKTTTQK IKRYGDNMKK
//
