ID   R7HY56_9CLOT            Unreviewed;       703 AA.
AC   R7HY56;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Glutamine synthetase {ECO:0000256|ARBA:ARBA00021364};
GN   ORFNames=BN648_01864 {ECO:0000313|EMBL:CDE43893.1};
OS   Clostridium sp. CAG:411.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262802 {ECO:0000313|EMBL:CDE43893.1, ECO:0000313|Proteomes:UP000018022};
RN   [1] {ECO:0000313|EMBL:CDE43893.1, ECO:0000313|Proteomes:UP000018022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:411 {ECO:0000313|Proteomes:UP000018022};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glutamine synthetase family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01330, ECO:0000256|RuleBase:RU000384}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDE43893.1}.
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DR   EMBL; CBIY010000073; CDE43893.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7HY56; -.
DR   STRING; 1262802.BN648_01864; -.
DR   Proteomes; UP000018022; Unassembled WGS sequence.
DR   GO; GO:0004356; F:glutamine synthetase activity; IEA:InterPro.
DR   GO; GO:0006542; P:glutamine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.20.120.1560; -; 1.
DR   Gene3D; 3.30.590.10; Glutamine synthetase/guanido kinase, catalytic domain; 1.
DR   InterPro; IPR040577; Gln-synt_C.
DR   InterPro; IPR008147; Gln_synt_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   InterPro; IPR008146; Gln_synth_cat_dom.
DR   InterPro; IPR027303; Gln_synth_gly_rich_site.
DR   InterPro; IPR022147; GSIII_N.
DR   PANTHER; PTHR42974; GLUTAMINE SYNTHETASE; 1.
DR   PANTHER; PTHR42974:SF1; TYPE-3 GLUTAMINE SYNTHETASE; 1.
DR   Pfam; PF00120; Gln-synt_C; 1.
DR   Pfam; PF18318; Gln-synt_C-ter; 1.
DR   Pfam; PF12437; GSIII_N; 1.
DR   SMART; SM01230; Gln-synt_C; 1.
DR   SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
DR   PROSITE; PS00181; GLNA_ATP; 1.
DR   PROSITE; PS51986; GS_BETA_GRASP; 1.
DR   PROSITE; PS51987; GS_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018022}.
FT   DOMAIN          64..157
FT                   /note="GS beta-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS51986"
FT   DOMAIN          162..593
FT                   /note="GS catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51987"
SQ   SEQUENCE   703 AA;  77400 MW;  95A285D5B242D262 CRC64;
     MGQNVIENVF AKDVFNDSVM RERLPKPIYK KLKKIMAEGQ DLDMEVANAV AHAMKEWALE
     RGATHYTHWF QPMTGITAEK HDSFIQPAGE GGIMLEFSGK ELVKGEPDAS SFPNGGIRAT
     FEARGYTTWD CTSPAFLKED AAGVILCIPT AFCSYTGEAL DKKTPLLRSM EAISNQAVRV
     LHVLGKEDVK NVSCSVGPEQ EYFLVDREKY LQRDDLIFTG RTLFGAMPPK GQELDDHYFG
     TLKEKIAAYM KELNEELWKL GILAKTQHNE VAPAQHELAP IYATANIATD HNQLVMEIMK
     KVAKRHGMEC LLHEKPFAGV NGSGKHDNWS LVTDQGENLL DPGKNPHENT QFQLFLAAVI
     RAVDDNAGLL RLSASNPGND HRLGANEAPP AIISIFLGEQ LQDVVDQIIK NGDATSSISG
     EKLVTGVSTL PDFMKDATDR NRTSPFAFTG NKFEFRMVAS ALSVAGPNTI LNTIVADVLS
     DFADQLEKSD DVEKTLHEII KKTLTDHQKV IFNGDGYSDG WVAEAEKRGL PNMKTMVDAI
     PELTSEKTVE MFGRLGVMDK VELEARAEID YESYSKAINI EAKTMVDMAG KKFIPAVINY
     VTDLAASINE INAACGGVNV DVQSDLLKKA SDLLAQAQKA KIALETSIAE AATKEEGTVQ
     ANFFKDVVKA DMDALRTPID ELEVIVGKEY WPVPCYADLL FEV
//