ID R7I759_9FIRM Unreviewed; 450 AA.
AC R7I759;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=peptidoglycan-N-acetylglucosamine deacetylase {ECO:0000256|ARBA:ARBA00044052};
DE EC=3.5.1.104 {ECO:0000256|ARBA:ARBA00044052};
GN ORFNames=BN770_01202 {ECO:0000313|EMBL:CDE47301.1};
OS Faecalibacterium sp. CAG:74.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Faecalibacterium.
OX NCBI_TaxID=1262897 {ECO:0000313|EMBL:CDE47301.1, ECO:0000313|Proteomes:UP000018328};
RN [1] {ECO:0000313|EMBL:CDE47301.1, ECO:0000313|Proteomes:UP000018328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:74 {ECO:0000313|Proteomes:UP000018328};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=peptidoglycan-N-acetyl-D-glucosamine + H2O = peptidoglycan-D-
CC glucosamine + acetate.; EC=3.5.1.104;
CC Evidence={ECO:0000256|ARBA:ARBA00043715};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE47301.1}.
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DR EMBL; CBJB010000042; CDE47301.1; -; Genomic_DNA.
DR AlphaFoldDB; R7I759; -.
DR Proteomes; UP000018328; Unassembled WGS sequence.
DR GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd10917; CE4_NodB_like_6s_7s; 1.
DR Gene3D; 3.20.20.370; Glycoside hydrolase/deacetylase; 1.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR002509; NODB_dom.
DR PANTHER; PTHR10587:SF105; CHITIN DEACETYLASE 1-RELATED; 1.
DR PANTHER; PTHR10587; GLYCOSYL TRANSFERASE-RELATED; 1.
DR Pfam; PF01522; Polysacc_deac_1; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
DR PROSITE; PS51677; NODB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018328};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..450
FT /note="peptidoglycan-N-acetylglucosamine deacetylase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004435546"
FT DOMAIN 225..405
FT /note="NodB homology"
FT /evidence="ECO:0000259|PROSITE:PS51677"
SQ SEQUENCE 450 AA; 49367 MW; 0B4034CA00AB5942 CRC64;
MKKWFCALGM MLALLMSVAL ADGVKVTFAE KNGQINGGYD YTLKLNVSPA SDKDLTVSLT
CDGLDGAYSV VIPAGQKSTM LTVPTQVVEE RGKVVFELQS GDGYTGAGKH TLTIQRLPNV
QFYLGINFGT VGKKMSVRMT VTNSSTIVKG NNTFQLRDDK GTVLAEAKWS NPSGDMSFSI
TPTADMEGYT RLSVWLGDRC VADGGYLTVV AKGQRAVKNV ETERKLVGIG MDCGFGGKNT
DQVLEVLAKH NTNITFFMTG YFVRTFPEES KRVLAAGNEI GDHTNTHPQL TKERPYSMMR
QIVFPAETMA ETLGVSPRLM RPPYGDVNSN VISVSRAEGM ECVLWNMSTK DSIGKYTVEE
CIKNGTTRAK LAPGNILLCH LDANHSWEIL DAVLTYYEEQ GYTVLPISAL IYATGGSLPP
MPSTREALLY TDDYWPNWLA ERGIEIETKE
//
