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Database: UniProt
Entry: R7IMT8_9FIRM
LinkDB: R7IMT8_9FIRM
Original site: R7IMT8_9FIRM 
ID   R7IMT8_9FIRM            Unreviewed;       310 AA.
AC   R7IMT8;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   12-APR-2017, entry version 23.
DE   SubName: Full=Chromosomal replication initiator protein DnaA {ECO:0000313|EMBL:CDE53074.1};
GN   ORFNames=BN596_00033 {ECO:0000313|EMBL:CDE53074.1};
OS   Roseburia sp. CAG:303.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae;
OC   Roseburia; environmental samples.
OX   NCBI_TaxID=1262944 {ECO:0000313|EMBL:CDE53074.1, ECO:0000313|Proteomes:UP000018355};
RN   [1] {ECO:0000313|EMBL:CDE53074.1, ECO:0000313|Proteomes:UP000018355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:303 {ECO:0000313|Proteomes:UP000018355};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDE53074.1}.
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DR   EMBL; CBJD010000046; CDE53074.1; -; Genomic_DNA.
DR   Proteomes; UP000018355; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018355};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018355}.
FT   DOMAIN        1    133       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      216    286       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   310 AA;  35340 MW;  6F5559FE4687C995 CRC64;
     MYNPLFIYGG VGLGKTHLMH SIGNFILDKD PSAKVRCVTS EIFTNELITA IRSENQQAIV
     EFRNKYRNID VLLIDDIQFV IGKERSQEEF FHTFNSLYEA NKQIVISSDK PPKDMSTLEE
     RLKSRFEMGL TVDVSAPDYE TRMAILLRKT ETENYDIDNE ILEYIANNIK SNIRELEGAL
     TKIVAFSRVS KTPIDLNFAK DVLKDIISPD ANREITPELI INTVAEHFHI SPADMASRIK
     SQDIVFPRQI AMYLCRHLTQ GSSLKSIGAL LGRKDHTTVM HAIEKIQHEI DTNESTKNTV
     EVIKKKIIPN
//
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