ID R7IN27_9BURK Unreviewed; 801 AA.
AC R7IN27;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=aconitate hydratase {ECO:0000256|ARBA:ARBA00012926};
DE EC=4.2.1.3 {ECO:0000256|ARBA:ARBA00012926};
DE AltName: Full=Citrate hydro-lyase {ECO:0000256|ARBA:ARBA00029682};
GN ORFNames=BN620_02037 {ECO:0000313|EMBL:CDE52037.1};
OS Sutterella sp. CAG:351.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sutterellaceae; Sutterella.
OX NCBI_TaxID=1262975 {ECO:0000313|EMBL:CDE52037.1, ECO:0000313|Proteomes:UP000018107};
RN [1] {ECO:0000313|EMBL:CDE52037.1, ECO:0000313|Proteomes:UP000018107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:351 {ECO:0000313|Proteomes:UP000018107};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 2/2. {ECO:0000256|ARBA:ARBA00004717}.
CC -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC {ECO:0000256|ARBA:ARBA00007185}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE52037.1}.
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DR EMBL; CBJA010000348; CDE52037.1; -; Genomic_DNA.
DR AlphaFoldDB; R7IN27; -.
DR STRING; 1262975.BN620_02037; -.
DR Proteomes; UP000018107; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 3.40.1060.10; Aconitase, Domain 2; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR015932; Aconitase_dom2.
DR InterPro; IPR006248; Aconitase_mito-like.
DR InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR InterPro; IPR006311; TAT_signal.
DR NCBIfam; TIGR01340; aconitase_mito; 1.
DR PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR PANTHER; PTHR43160:SF3; ACONITATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF00330; Aconitase; 1.
DR Pfam; PF00694; Aconitase_C; 1.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 85..528
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 607..733
FT /note="Aconitase A/isopropylmalate dehydratase small
FT subunit swivel"
FT /evidence="ECO:0000259|Pfam:PF00694"
SQ SEQUENCE 801 AA; 87177 MW; 6B410C605D8A1EA3 CRC64;
MESQNKFQVS RRTLLKDTAI GAAGVSTMGI ADIASAATKQ SAKKAHKAPT AQIRNFDMIE
AFYANYPKKL AAVRSKLNRP LTLSEKILYT HLYDPEAVKE YKRGASYAEF RPDRAGTHDI
GGPMAILQFM VSGKKKIALP AAMVCDHLVT ANAGARKDIA FADHYNKETY DFLRTVSRRY
GFDFWPAGSG ICHQVFLENY DFPGGMMLVT DSHTPTACGL GMLAIGVGGA DLVDALMGSE
WELKMPKLIG VKLTGKLQGW ASPKDVILRV AQILTTKGGT NCIIEYFGDG ANTISATGKA
TIGNMGAEVG STTSVFPYDS HMKAYLKATN REAVADLADG VAKDLQADPE VYAHPEKYFD
RVIELNLSEL KPLINGPLSP DAAMELDQVG DTLAKKNIPE NIEVALVGSC TNSSYEDFTR
AASIVKQCLD KGVKIKTPLI VVPGSVRIRE TLKRDGILQQ FEKLNATVMT TACGPCIGQW
DRHIGDKTKV NTIIESFNRN FAGRNDGSKK TQAFLASPEI VVAMAINGDM RFNPLKSTVT
GANGISFKLA TPVGEELPAK GFATNVGGCI IPDFKQVPVV VAPNAERIRL LTPFPAWNGK
DYVDLPLLIK AKGKCTTDHI SPGGKWLPYR GNIDRISDNL LERATNAFNG KSQSVWNVVN
KDYESPAKTA RLYKNKGIQS IIVGDDNYGE GSSREHAAME PRYLGVVVVL AKSLARIHES
NLKKQGVLAL TFVDPKDYDK IREKDRISVL GLSQIAPGKT VTIVCKHEDG TEDRFQAQHS
YNAKQLTWFR AGSAMNALGK A
//
