ID R7IZB5_9FIRM Unreviewed; 459 AA.
AC R7IZB5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=N-acetylmuramoyl-L-alanine amidase {ECO:0000313|EMBL:CDE55957.1};
GN ORFNames=BN596_00547 {ECO:0000313|EMBL:CDE55957.1};
OS Roseburia sp. CAG:303.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1262944 {ECO:0000313|EMBL:CDE55957.1, ECO:0000313|Proteomes:UP000018355};
RN [1] {ECO:0000313|EMBL:CDE55957.1, ECO:0000313|Proteomes:UP000018355}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:303 {ECO:0000313|Proteomes:UP000018355};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE55957.1}.
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DR EMBL; CBJD010000271; CDE55957.1; -; Genomic_DNA.
DR AlphaFoldDB; R7IZB5; -.
DR STRING; 1262944.BN596_00547; -.
DR Proteomes; UP000018355; Unassembled WGS sequence.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd02696; MurNAc-LAA; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.630.40; Zn-dependent exopeptidases; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002508; MurNAc-LAA_cat.
DR PANTHER; PTHR30404:SF5; AUTOLYSIN PH-RELATED; 1.
DR PANTHER; PTHR30404; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; 1.
DR Pfam; PF01520; Amidase_3; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018355};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..459
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038958572"
FT DOMAIN 215..428
FT /note="MurNAc-LAA"
FT /evidence="ECO:0000259|Pfam:PF01520"
FT REGION 28..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 50276 MW; B2824B0514FE3AEB CRC64;
MKKYIAAFFV CVAALVIAGL LLQNQTDIDR SSGEQDTKKA EKITTEDKEE SRESETGISQ
VSEDKSEETE AEVTEEPGEL QKTTEPVTEE RTEKVSERKT QPANRTPVSV AEVQAQRNTA
DSINVSWTNE MDGCVSRYVV QKRKAMRNEN AVEWTEVARV DAGLAEQTDG QYMITDVLDS
DQPVRYEYRV QVEVKDEKQY EPQDGGSVLA SNIMICIDPG HYAGKNEVTG SESYGYAEGD
FTLKVATALK SDLKEIYGID SYMTRTTGTI TLGGYTNLSL DRAHISLRGE YAAERDSTLF
LSIHTNANEE NANGYDTCLQ PVSINKSLVF VNMVAKKSDT ILSVSNAIGT GLTRVNYDMG
LSTVGEFRTA TADTVLEWTK AYNDSLNTGG TVVCRTDGKE DYYGVLRGAS SVGIPGLIVE
HGMHTIPEVR KAALGDLAEQ WADADAYGIA YGFGFAGEK
//
