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Database: UniProt
Entry: R7JYH0_9CLOT
LinkDB: R7JYH0_9CLOT
Original site: R7JYH0_9CLOT 
ID   R7JYH0_9CLOT            Unreviewed;       227 AA.
AC   R7JYH0;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   25-OCT-2017, entry version 21.
DE   SubName: Full=Chromosomal replication initiator protein DnaA {ECO:0000313|EMBL:CDE68691.1};
GN   ORFNames=BN584_02682 {ECO:0000313|EMBL:CDE68691.1};
OS   Clostridium sp. CAG:277.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium; environmental samples.
OX   NCBI_TaxID=1262790 {ECO:0000313|EMBL:CDE68691.1, ECO:0000313|Proteomes:UP000018281};
RN   [1] {ECO:0000313|EMBL:CDE68691.1, ECO:0000313|Proteomes:UP000018281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:277 {ECO:0000313|Proteomes:UP000018281};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|SAAS:SAAS00747914}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDE68691.1}.
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DR   EMBL; CBJK010000051; CDE68691.1; -; Genomic_DNA.
DR   Proteomes; UP000018281; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018281};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018281}.
FT   DOMAIN      131    200       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   227 AA;  26163 MW;  DDC756E196C1D40E CRC64;
     MQQEFFHTFN HLYESQKQIV ISSDKHPATM KTLEERLRSR FEMGLTVDIK PPTYETRMAI
     LRRKVQEENL SIDDSILDFI ASNVSSNIRE LQGAITKVIA FSKLRHNDIT MDLAKQALSD
     MIAPDKKKEI TIDYIIETVA DHFNISTNDL LSSKRSSNIS HPRQICMYLC CELTNNTLDV
     IKKHLNRKDH STIIHGRDNI KKLLEDTDAN SKVAKDIDIL IKKINPQ
//
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