ID R7L5T7_9FIRM Unreviewed; 1187 AA.
AC R7L5T7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN ORFNames=BN622_00481 {ECO:0000313|EMBL:CDE82587.1};
OS Ruminococcus sp. CAG:353.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1262955 {ECO:0000313|EMBL:CDE82587.1, ECO:0000313|Proteomes:UP000017936};
RN [1] {ECO:0000313|EMBL:CDE82587.1, ECO:0000313|Proteomes:UP000017936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:353 {ECO:0000313|Proteomes:UP000017936};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE82587.1}.
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DR EMBL; CBJQ010000228; CDE82587.1; -; Genomic_DNA.
DR AlphaFoldDB; R7L5T7; -.
DR Proteomes; UP000017936; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Reference proteome {ECO:0000313|Proteomes:UP000017936}.
FT DOMAIN 523..639
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 167..201
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 227..275
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 304..366
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 402..429
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 458..492
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 680..840
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1187 AA; 132788 MW; 3610810457CAF353 CRC64;
MYLKSLELQG FKSFPDKVKL DFGKGITAVV GPNGSGKSNI GDAVRWVLGE QSSKTLRGAK
MEDVIFAGTQ LRKPVGFASV TLNIVNDKGL LNIDAPEVSV TRKLYRSGES EYIINGSQVR
LKDVTELFMD TGLGKDGYSI IGQGRVAEIV SSKSNERRDI FEEAAGISKF RYKKAEAQRR
LTQAEDNILR LTDIISELES RVEPLRKQSE KAAQFIELSD EKKSLEITVW MHELDELRTR
LNELGEKVLI NATEYNNTET DIDRLEEEYR IVYKDIAAGN IRIENLNNAV LEEERSNTAI
HSDIAVFKND IEHCRKAIED LEKQMESAKL SDSENRRLTE EKLEEIKRIE ADILTTDREY
SDAEREFAEA VGQQDGFEKE FSGHSEQLNK MYIRQSELNI TVNTSDNMIK EAEEQKQAAE
KQLETIVSGA QNLDSERKEV TDGLALLAEK RDEQTNRISG LNRLYASKTE KLKAAEKEQN
DLTMSVREKE QKMRLLRDLE NSMEGFGHAV KQVLSAGKNG RIRGIIGSVA QIISVPSEYS
LAVETALGGA LQNIVTENED AAKRGIGLLK ETKGGRATFL PITSVKGNRL NESGLDGCVG
FVALGCDIVT YDPKFTGIVN SLLGRTVIAE DIDCAGNIAK KYGYRFRIVT LDGQVVNAGG
SFTGGSANRS AGILTRKNEI EKLNGEVTDL TGKLDELKSR TASLRAETDK MRIDIEAAND
DLRAMDQDKI RFESELKRIE QVAEQSVNGR KNAEETIARF EKRLSDIRAA AEKAGAELAR
LCQEISAAEE KSGEDKRIMD ELKSRRDSLS SKMSDMKIKK TALEKDLEAV KESIKALEEQ
SRSIGDSSVR SAMAIEEQNR IIAEKNELIA KREKALESSG SRTEDIHRQI SLTQAENLEK
ERQSVEIRQK IKVLTDDKEK LGAEKTRLEE RRKTSQSAYD KIVSDMAEQY ELYPSEAASL
IIPDADKGEI TARLNTIKQK IRNLGTVNLS AIEEYKEVSE RYEFMSGQLS DINSSKRELE
KLIDELTETM KTRFAESFKE INANFKRIFT ELFGGGRAEL VLTDPDEVLE SGIEINVAPP
GKVIKNLSLL SGGEQAFVAI AIYFAILKIK PAPFCILDEI EAALDDVNVS KYAHYLRNFT
DTTQFITVTH RRGTMEEADV MYGVTMQEKG ISRLLKMEQP PADIEAE
//
