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Database: UniProt
Entry: R7MFH2_9CLOT
LinkDB: R7MFH2_9CLOT
Original site: R7MFH2_9CLOT 
ID   R7MFH2_9CLOT            Unreviewed;       297 AA.
AC   R7MFH2;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   25-OCT-2017, entry version 23.
DE   SubName: Full=Chromosomal replication initiator protein DnaA {ECO:0000313|EMBL:CDE99814.1};
GN   ORFNames=BN790_01478 {ECO:0000313|EMBL:CDE99814.1};
OS   Clostridium sp. CAG:813.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium; environmental samples.
OX   NCBI_TaxID=1262843 {ECO:0000313|EMBL:CDE99814.1, ECO:0000313|Proteomes:UP000018381};
RN   [1] {ECO:0000313|EMBL:CDE99814.1, ECO:0000313|Proteomes:UP000018381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:813 {ECO:0000313|Proteomes:UP000018381};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDE99814.1}.
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DR   EMBL; CBKA010000234; CDE99814.1; -; Genomic_DNA.
DR   Proteomes; UP000018381; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018381};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018381}.
FT   DOMAIN      206    274       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   297 AA;  34674 MW;  23EF1F33E5041A93 CRC64;
     MQAIGHYIIF NKPDLKVRYV RMEEYFNEWM KCFQLNDLPN GKKKQFRNNS LMRKFHQKFQ
     NVDVLLMDDI QFIESKMKTM EDFFSTFEAL YTNNKQIVIA SDRLPKDIPT LDNRLRTRFE
     MGLVVDIVPP DYETRFEIVK AYAQELEVEA DDDVFEYVAE NFVNNVRELK GAFNKISAYA
     EFSGTGLTLD LAKRVLNCEA KKKEITVSTI AQKVADYFDL TVKDLKSTAR QQKIAHARHV
     AVYLAREVLQ MSYEAIGEFF SKKHTTIMYS CDLVADKLKT DEDLKISIEE IKASLRN
//
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