ID R7N3Y0_9FIRM Unreviewed; 607 AA.
AC R7N3Y0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BN816_00205 {ECO:0000313|EMBL:CDF08219.1};
OS Firmicutes bacterium CAG:95.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1262988 {ECO:0000313|EMBL:CDF08219.1, ECO:0000313|Proteomes:UP000018182};
RN [1] {ECO:0000313|EMBL:CDF08219.1, ECO:0000313|Proteomes:UP000018182}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:95 {ECO:0000313|Proteomes:UP000018182};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDF08219.1}.
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DR EMBL; CBKF010000193; CDF08219.1; -; Genomic_DNA.
DR AlphaFoldDB; R7N3Y0; -.
DR STRING; 1262988.BN816_00205; -.
DR Proteomes; UP000018182; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd18774; PDC2_HK_sensor; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CDF08219.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018182};
KW Transferase {ECO:0000313|EMBL:CDF08219.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 478..585
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 356..388
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 607 AA; 70240 MW; 2A4C62F77DDD2C13 CRC64;
MMKKKRRASD IQSVIMTVLS LMTVITSISM GLLLYNRYET AMRQNDVRDA QNMMETIVNS
MEQYLKSMRQ ISDTANYNII QALDISSPEF NQELSLLYDS NKDKIQSIAL YDMEGELLVA
EPVTLQKEGV EVSRQSWFEN AKAKIENMHF STPHMQDLFQ DDAKRYHWVI SLSRAVDVID
GDSPENGILL VDMKYSFIEE MMDRINDRTR GRYYYLCDRE GKLIYHPYAN EISNGLFQEN
SVLASSSEDG IYRNLRSPHG ERQTMIVNTI SYTGWKLVGV VLPDIRTDSL EKFRIYMMII
VIMLIMMLLA VNRIVSKKIS SPILKLDASV TAYEAGEKPD IYIGGSYEIR HLGNSVQKSY
EEIERLMKEI VEQQNERRKS ELAALQSQIN PHFLYNTLES ITWMIEGNRN QDAVFMISEL
ARLFRISLSR GKTIIRIEDE LQHCRNYMNI QKYRYKERFV TEYDVSEEIY PFCTVKLILQ
PILENAIYYG VGDMDEDDHP RILVRGFKKE EEIYLVVSDN GMGMRREDVE NILTDNQKVP
KHGSGVGLIN VHTRIQLMFG VRYGLKVDSE PDEGTTVTIH LPAIPYTKEN CEILEAPGKP
PRNEVEP
//
