ID R7P598_9CLOT Unreviewed; 1216 AA.
AC R7P598;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=MMPL family protein {ECO:0000313|EMBL:CDF20894.1};
GN ORFNames=BN733_01054 {ECO:0000313|EMBL:CDF20894.1};
OS Clostridium sp. CAG:609.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262827 {ECO:0000313|EMBL:CDF20894.1, ECO:0000313|Proteomes:UP000018389};
RN [1] {ECO:0000313|EMBL:CDF20894.1, ECO:0000313|Proteomes:UP000018389}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:609 {ECO:0000313|Proteomes:UP000018389};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDF20894.1}.
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DR EMBL; CBKL010000040; CDF20894.1; -; Genomic_DNA.
DR AlphaFoldDB; R7P598; -.
DR STRING; 1262827.BN733_01054; -.
DR Proteomes; UP000018389; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 511..673
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1216 AA; 134929 MW; D3D411978DEDECA3 CRC64;
MKKFANYIAN HSALVLIISL VLLIPAIIGY VNTRINYDIL VYLPDSVDTI KGENILTDDF
GLGAYAFVMV DSNNSKNILN LEKDIKKIDG VNAVMSLADL TDTTIPVDML PSKVVDKLDK
DNETIIFVTF EGGTSEDDTI EAVRQLRKTV KDDTKVSSMT SMVIDTMDLS NKEIFTYVVI
AVALCLTVLL LATDSYVIPF LLLGNIGIAI IYNLGSNIFL GQISYITKAI TAVLQLGVTM
DFSIFLYHKY EQAKQNNKKL KKTEAMSEAI IETFQSVLGS SLTTFAGFLA LCTMDLTLGT
DIGLVMAKGV LCGLICVITL FPALLMIFDK MVEKTKHKVI LPEFKRIQDF SVNNYKAIIV
AFLILLIPAF YGNNHYKVYY KLDDSLPEYL AFNVANSELA EKFNIVSPEI ILLDKNVKSN
EVNKLVSDLE NIEGIDLVLA PNSFVDPAMM MLLPNDLTKI LDNDNYQLVI VNSTYELASD
ELKNQIGEIE EVVKKYDENS IIAGEGPLMN DLVTIADHDF KMVNYTSILV IFIIMILVLK
QINLPIVLIL TIEFAIFCNM SVAYYTSTTL PFIASIVVGT IQLGATIDYA ILMSTKYLEE
RSEQSDKFSA MKKTLSLTVP SIITSALCFF GATFGVSAYT KIDMIGSICE LLARGSIISM
IVVVTILPSL LLVTDKLIVK NKKKEGKDMK KLKTASLIGL SLLLLPFNAS AAKTESIYTK
LDYNGDTVKS TVSNHIENDK NGEVKDNTIL SNILNVNGDE TFTLDKDTLT WYAKEKDIFY
QGTTDKELPL STVVKYYYNG KETDAKDIIG KSGKIKIEIR LLNNSLLNKN NRFTPFVVAI
GTTIDNETNK NISITNGKVT DTGSRNIAVA ISSPGLYEYT NIKEFKDLNK VVISYETTDF
EINDIYMVAS PKLLSDLDFD IFNKLDEFSS SIDTLSSKMD DIENGAKKLY DGSSALVSGE
AKFNSKLTYL ATSLEKISNG TLALNDGIDE MIETLTSVKE MMANKDLNGS LANLQVLYQT
NSATIKKISN EKVDATYKYY QMSQTETEDA MVERLKQMNP NIDEATLVNL KNVKSTYELK
LLLTANNNAI SEMITNLQDL NTLLNTLDAK LQEVKVMKSK VTYLNDSLSQ VSQGLTKMSQ
TTLITDGISS LNQGLKELSD GTNLINIQGI KQLVNYKNQV LTYTNKFKDI ANLSKSYQGF
SSNNSDQTVF IYKIGK
//
