ID R7R5I7_9FIRM Unreviewed; 554 AA.
AC R7R5I7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BN450_01914 {ECO:0000313|EMBL:CDF45353.1};
OS Roseburia sp. CAG:100.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1262940 {ECO:0000313|EMBL:CDF45353.1, ECO:0000313|Proteomes:UP000018092};
RN [1] {ECO:0000313|EMBL:CDF45353.1, ECO:0000313|Proteomes:UP000018092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:100 {ECO:0000313|Proteomes:UP000018092};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDF45353.1}.
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DR EMBL; CBKV010000169; CDF45353.1; -; Genomic_DNA.
DR AlphaFoldDB; R7R5I7; -.
DR Proteomes; UP000018092; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CDF45353.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018092};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 16..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 289..341
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 450..554
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 554 AA; 64416 MW; 99171ED323592D3A CRC64;
MNKKTTTFQE NIRNTFISYA IIPSLILVCL AMLLFYWSRN YSIIHYNRQD NEQITHTLEA
IENTWSTEVS NLCDLAKDEP TQKITDIYEI IYAADRSNRC SSQVYLLDGK GALIWNVEDA
DMDFLLQPEY QQWGILRMIR QQPETLSTYI QNDFLCMGQG ILDENGKFLG YLVVGIPGRE
CADILSGINR KYAITDEMGW IYLSNSTEYL SDEMGRFLWF DKKQDGFFTE NNQHFYLTQN
YILSGQIGVY TMTDTDPKVH IMWWMILMIV VIFAIIGIVT YYSTRKVSAK YTQDVKLLAD
AFTSVENGEW NTSLTMDSTL EFQVIGKAFN KMIDSMHKQM EENKELALHA AFAQVKQLES
QFNPHFLFNT LDNIRFMIHI DSNAADKMIT SLSKLLRYSI HDSGEEISVK EDMENIQSYF
NILQIRYNKR FAYEVNIEES ILDCMIPKLI MQPLVENAVK YGFTDRDKLT VKIKGYEKQG
RLIFSCEDDG AGMTPQQLKD IRRRLQQKEN KEGHLGLYNI HRRIQLMYGE EYGIFLESEI
GQGVVVVLVL PVKR
//
