ID   R7R9B6_9FIRM            Unreviewed;       674 AA.
AC   R7R9B6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=FAD-dependent oxidoreductase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN450_02743 {ECO:0000313|EMBL:CDF46345.1};
OS   Roseburia sp. CAG:100.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=1262940 {ECO:0000313|EMBL:CDF46345.1, ECO:0000313|Proteomes:UP000018092};
RN   [1] {ECO:0000313|EMBL:CDF46345.1, ECO:0000313|Proteomes:UP000018092}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:100 {ECO:0000313|Proteomes:UP000018092};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDF46345.1}.
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DR   EMBL; CBKV010000267; CDF46345.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7R9B6; -.
DR   Proteomes; UP000018092; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR003953; FAD-binding_2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR   InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR   InterPro; IPR030664; SdhA/FrdA/AprA.
DR   PANTHER; PTHR11632:SF73; BLR3196 PROTEIN; 1.
DR   PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR   Pfam; PF00890; FAD_binding_2; 1.
DR   Pfam; PF02910; Succ_DH_flav_C; 1.
DR   PIRSF; PIRSF000171; SDHA_APRA_LASPO; 2.
DR   PRINTS; PR00368; FADPNR.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
PE   4: Predicted;
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018092}.
FT   DOMAIN          43..283
FT                   /note="FAD-dependent oxidoreductase 2 FAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF00890"
FT   DOMAIN          538..632
FT                   /note="Fumarate reductase/succinate dehydrogenase
FT                   flavoprotein-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02910"
SQ   SEQUENCE   674 AA;  75680 MW;  1A3B68BCC20B4645 CRC64;
     MKYLRVTGQP ALMYKEKGHN GNMETYNWPY GNELGEREEA ACDVLVLGGG LAGCYAAIAA
     ARRGQSVILV EKGNTEHSGS AGTGFDHWES ACTNPCSEVT PEEIAWAYVH EQDGYSNGIA
     HYIECREGYD RLIDMEAFGG KVRDTEGEFE GAAFRDEKTK LMFAYDYKNK FTLRVWGSTF
     KPALVKELKR LGVRIYDRTE ATALLTAIEN GKKRGIGAMG MNVRTGKFMI FRAKTTVLTM
     SRPARVWLFN PDTVGLCEFR PMQSIGSGHA MGYRAGMEFT MMEKSVRAEF SAAGRSFPPY
     GAGNNHNTWY AATMVDARGV EIPYVDRDGK ELKTVLERYM PAKGQKFFLK GGVIDNPKYE
     YRGPETLDFD ELMKRGYKLP FYADLSRMPD EERRVIWGMM VGEEGKTKIP ILENYTRRGF
     DSSKHMLQSY GTGWQSANFL EQERQLFGAP GGIMHDWDLK TNIEGIYAAG DQLYASDCAG
     FACATGYYAG RKAAAAAGEL ELAEYDKEQV EEEAERLYAP LYADADAGMN WKELNMAISK
     AMQNYCGGVK CDALLKEGLN LLDTYKKEFV PRLYCTNPHD LMRTHEVLDI LTVAELILQA
     CLLRRESSET LCFARTDTDA VEEKGKGKHI VLRQENGRII SREVPLDFFG DLKTEYEKRN
     ADYIASGEVP THEA
//