ID R7S9K9_TREMS Unreviewed; 3440 AA.
AC R7S9K9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=TREMEDRAFT_35527 {ECO:0000313|EMBL:EIW66046.1};
OS Tremella mesenterica (strain ATCC 24925 / CBS 8224 / DSM 1558 / NBRC 9311 /
OS NRRL Y-6157 / RJB 2259-6 / UBC 559-6) (Jelly fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Tremellaceae; Tremella.
OX NCBI_TaxID=578456 {ECO:0000313|EMBL:EIW66046.1, ECO:0000313|Proteomes:UP000054539};
RN [1] {ECO:0000313|Proteomes:UP000054539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fries {ECO:0000313|Proteomes:UP000054539};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; JH711544; EIW66046.1; -; Genomic_DNA.
DR RefSeq; XP_007007999.1; XM_007007937.1.
DR GeneID; 18492705; -.
DR KEGG; tms:TREMEDRAFT_35527; -.
DR VEuPathDB; FungiDB:TREMEDRAFT_35527; -.
DR eggNOG; KOG3595; Eukaryota.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000054539; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054539}.
FT DOMAIN 754..892
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1049..1293
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1417..1567
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1759..1925
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 3165..3186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2021..2083
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2239..2287
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3440 AA; 388532 MW; 4C788114E455FDED CRC64;
MKETYSGILK SRTDLETMSI DGTSTAQAVT FITLVQELKR KSKVWGPEME LFLLGQKTLE
RQRFTFGTEW LYVDQVQGEW SAFTDILKRK DDAIQEQIAG LQLKIVAEDK VVDGRIREFT
SEWETLKPLQ GSIKADVAIN TLNVFEGRLT RLLEEYDLVC RAKEALNLEH TKDDRLEPVT
EELRDLKGVW TALSGIWGRI GQLREMLWSA VQPRKLRQEL DAILSSTREM PSRMRQYAAF
EYVQETIRGL LKSNVLISEM KSEALRERHW SKLYKALRMS GASQSSTMTL GQVYDLDLRK
NEQLIKEVVM QAQGEMALEE FLKQVRETWT SYALDLINYQ NKCRLIRGWD DLFNKCGEHL
NSLNAMKLSP YYRVFEEEAA SWEEKLNRVH VLFDVWIDVQ RQWVYLEGIF TGSADIKHLL
PVESARFQNI NSEFLTVMKK VNKSPFVLEI LNIPGIQKSL ERLADLLTKI QKALGEYLEK
ERSSFPRFYF VGDEDLLEII GNSKDIRRVM KHLKKMFAGI STLQLDEDET MLLGFASREG
EEVSFRSPIM LKDFPKINDW LARVESEMRH SLAESLFRAV TELRTLFAID SELSLPGLMT
WIDSYPAQLV VLAVQVAWTE LTENALESNS LTNVLTLVAK TLDLLADTVL QDIAVLQRRK
CEHLITELVH QRDVIRGLIS NGIRSSSSFD WLYYMRFYLI DTIEDPLLRL EVRTADAIFP
YGYEYLGIPD RLVQTPLTDR CYLTLTQALD NQLGGSPFGP AGTGKTESVK SLGVQLGRFV
LVFCCDETFD FQAMGRIFVG LCQVGAWGCF DEFNRLEERI LSAVSQQVQS IQQGLAEITF
NPDAEVELVG KKLKVNPRTG IFITMNPGYA GRSNLPDNLK KLFRSMSMTR PDQELIAQVL
LFSKGFRTAE ILASKVVPFF NLCAEQLSNQ PHYDFGLRAL KAVLSSAGIL KRDRYLKSVD
GELEVEGDDV VEQQIMIQSV TETIVPKLVA DDVPLLKGLL QDVFPGIAYV PVDLEALRTK
IAEVCAERHL VPGEAWVDKV VQLYQIQNIS HGLMMVGPSG TGKTQAWQVL LAALERVDGV
EGTSYSIDPK AIDKESLYGT LDPTTREWND GLFTHILRKI VDNVRGETTR RHWIIFDGDV
DPEWVENLNS VLDDNKLLTL PNGERLNLPP NVRVMFEVEH LRFATLATVS RCGMIWFSED
VISTSMICQN QLRLLSTVPI GGDDEEIADF GTSSSSSSGR LEAQKQMVSM LQKQFGEGGI
IMSALDFAST SQHIMDFTPI RALNTLFSLL KATMRNVLEY NARHADFPLS PEKVESYITR
RLLLNVVWAF SGDGRLESRA DLGQHLQLQS GVEMPPLTIG GSLIDFDVDV GSGAWISWES
RVPTVEVETH AITASDIVIP TIDTVRHEEV LYSWLAEHKP LILCGPPGSG KTMTLFSALR
KLPDLEVVGL NFSSATTPEL VLKTFEQYCE YRKTPNGVIL SPTQIGRWLV VFCDEINLPS
VDKYGTQRVI SFLRQLIENN GFWRTSDLSW VTMERIQFVG ACNPPTDPGR VPLSHRFLRH
APVVLVDYPG ETSLKQIYGT FNRALLKVIP TLRGHAEALT SAMVGLYRAS QTRFTADIQA
HYIYSPRELT RWSRGIFEAI KPLETLSVEG LIRVWAHEAL RLFQDRLVSE EEKKWTDEMI
DSTAREHFNN VDLKEALSRP ILYSNWTSRH YIPVDRDQLR EYTKARLRVF HEEELDVPLV
LFNDVLDHVL RIDRVFRQIQ GHLLLIGVSG GGKTTLSRFV AWMNGLSIFQ IKVSNKYTGA
DFDEDLRTVL RRAGCKGEKI CFIMDESNVL DSGFLERMNT LLANAEVPGL FEGDEHAALM
TACKEGSQRD GLMLDSHEEL YRWFTQQVAR NLHVVFTMNP PANGLASRAA TSPALFNRCV
LDWFGDWSDQ ALYQVGWEFT QTLDLDVASY NPPIPFPAVY RELPRNPSHR SAVVNAMVFV
HQSMRAITSR LAKSQGKYNH ITPRHFLDFI NHYVRLFNEK KEELEEQQRH LNVGLDKLRD
TVSQVEELRT SLAAKSKQLE AKNAEANLKL RQMVSDQQEA EAKKAASIEI RAALEQQDAY
IKERSQIVKE DLAQAEPAVL EALAAVGNIK KQHLSEVRSM ANPPEAVKLA MESACSVLGH
QIDSWKTVQS IIRRDDFISS IQNFDTKKMS KGVRDRMMRD YVSKPAFNYE TVNRASRACG
PLVQWVIAQV RFSEILDKVA PLRNEVASLE NQAETTKQQA KVVEDTVAEL EASIARYKEE
YALLISETQA IKSEMDRVQT RVDRSMTLLQ SLSSEQQRWD SGSKTFEAEM STIVGDVLVS
AAFLAYSGFF DQRYRDTMRT EWSEHLSEAG IAYKSDLALA EFLSTADQRL GWQSNALPAD
SLCVENAVML KRYQRYPLIV DPTGQAATFL QNEYRERKMT VTSFHDESFL KNLESALRFG
NPLLIQDVEN LDPILNSVLN RELRRTGGRV LIRIGNQDID FSPSFTMFLS TRDPSVDFPP
DICSRVTFVN FTMTRSSLQT QALDKVLRAE RPEIDQKRQD LMKLQGEFRL RLRHLEKSLL
QALNESEGSI LDDDKVIGTL ETLKKEAAEI GRKVEDTETV MMEVDAVTSE YLPLAQACSG
IYFTLEQLAT INHFYQFSLD FFLEIFDSVL LQNPNLKGVS DAASRRETLF KDLFLMAYKR
TSRALLHTDY LVFTATLAKL RLRGEELAVV SDELDALLDV PAGIDRTSLK LSGEQRRVLE
SHLGLNVVKT LEEDLSANPN EWHSFITDAK PEKNVPWPWA PANGITTSAR KVILIKLFRP
DRLLQALSMF VDQAFDIDLA SQSETELRKI VLEEITPSHP VALTSVPGYD ASYRVDNLCK
VVGVSCTPVA MGSVEGFSLA DQAIANAART GSWVLLKNVH LSPAWLSQLE KRLHSLTPHP
SFRLFLTMET SPVIPVNILR QSRIIMNEPP PGVRANLLDS LQSLPQSRLS SGPAEKPRLF
FLLAWFHAVV QERLRYLPLG WSKAYEFNDS DFDAALGTID TWLGSLAKGK ANVDPAQIPW
IALRTLIKQA VYGGRVDSDF DQRIVDAFVD RIFSPKAYDA DFMLVDRAEG GLAGPEGTQI
QQYIKWTQAL PEREPPAWLA LPGSAEGLVA VAEGEGVMNK LRKMRTLDDE DDGSSSPTST
LAGRPGWMTT LKSHAQEWLQ NLPETLSTPS DKNSPLARLF VREAARGKSL LSRIRRDLNE
LIGVCDGTLK QTNELRTLIS DLNTEGTVPT HWRKFKMPSG TPVQIFVSDL RARLQQLQNI
AIGVQKGGVW LGGLFQPEAY ITATRQTVAH AQGWSLEQLV MRLEVEVEGG ENSFAVEGLK
LEGAGWKEGK LTLNDGESTS LGTCQIRWYK INTLPNLETS VNIPVYLNKE RKDVLFSVDL
STTGLSQAIV AQQGVCITNI
//
