ID R7SKY7_DICSQ Unreviewed; 1002 AA.
AC R7SKY7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=DUF221-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DICSQDRAFT_93028 {ECO:0000313|EMBL:EJF56821.1};
OS Dichomitus squalens (strain LYAD-421) (Western red white-rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Dichomitus.
OX NCBI_TaxID=732165 {ECO:0000313|EMBL:EJF56821.1, ECO:0000313|Proteomes:UP000053319};
RN [1] {ECO:0000313|EMBL:EJF56821.1, ECO:0000313|Proteomes:UP000053319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LYAD-421 SS1 {ECO:0000313|EMBL:EJF56821.1,
RC ECO:0000313|Proteomes:UP000053319};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; JH719462; EJF56821.1; -; Genomic_DNA.
DR RefSeq; XP_007370412.1; XM_007370350.1.
DR AlphaFoldDB; R7SKY7; -.
DR GeneID; 18844994; -.
DR KEGG; dsq:DICSQDRAFT_93028; -.
DR HOGENOM; CLU_009187_0_0_1; -.
DR OMA; GKGFFAW; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000053319; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053319};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..174
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 199..362
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 375..656
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 913..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..974
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 113216 MW; B4633911E04A986F CRC64;
MSAEDTLGGF VDETTSQRQL APVAVASQVA LMSGISLATI VIFNVLRPRN KIVYEPKVKY
HVGNKVPPRA SDSFLGWVSP LLHTKEPELV DKIGLDAAIY LRFVRMCRWL FTAIAVLTCA
VLIPVNVVYN LRTVPSKSRD ALSMLTIGEL KHEWVIPHVV VTYLITFLVI GFVYVHWREV
VRLRREWFRS PEYLQSFYAR TLMVTDVPKK LQSDEGLRAI FESVQVPYPT TSVHIGRKVG
RLPELVEYHN DAVRELEQVL VKYLKGGKIG KKRPTITVGS TVGCGGEKKD AIDHYTNKLQ
RADRAVEEFR KQIDLRKPEN YGFASMAAVA YAHIVANMLR GKHPKGVTIT LAPNPKDIVW
KNLGRSKAEI RRAQTIGWLW LIAICTFNTI PLLIISVLAN LSSLTAFVPF LESWSEESPH
SFTFVSGVLP PAVSALFGWA LPIIMRKLTK FMGAYTHSRM DRAVVARYFA FLIISQLVIF
TLIGVLFNAA TIVIQSIGKH LSFVEIMNRL KDIPENINST YINQSSYWLT YFPLRGFLVL
FDLAQLLNLA VVFFKTHFLG RTPREIREWT QPPDFQFAIY YSNLLFMGTV GLFFAPLAPL
VAVAAAIVFW ISSWVYKYQL MFVFVSKTES GGRMWNVVIN RLLFSVILMQ CIVILTIGLK
SSFKSFYWIA TIPPILFILA FKYYIHRVFQ PHFRYYMPSE SELREAQVHS RRNDATNNRL
EKRFGHPALH SELFTPMVHA NMTHLLPQVY SGKVSNVQTK VEDMGGQKMD ATMVAGGIKI
AGIEERDLEY DPALYQRDRG DDWDTRSISS SNLLSESKGM YPDAGRASPA PSKMANFDRY
LAYGAQPEIE MNRLDIPDNQ PLLNQPASPG YFDASLGASR SNVNLDYVIT PPDGSQTPLL
PAAYPSEEYR EAPLHRPYPS QGYSSQYSPP QQYTPTQQYP PQQYQRPQRY PSPAPSQIFY
PSQTGVTPQR ASPESVMSHP PVPPPGLDDG EMNMAGRGAH RS
//
